Evidence map›Paper›PMID 38180338›Full record

ArticleRadiology. Imaging cancer2024

Breast Multiparametric MRI for Prediction of Neoadjuvant Chemotherapy Response in Breast Cancer: The BMMR2 Challenge.

Wen Li, Savannah C Partridge, David C Newitt, Jon Steingrimsson, Helga S Marques, Patrick J Bolan, Michael Hirano, Benjamin Aaron Bearce, Jayashree Kalpathy-Cramer, Michael A Boss and 22 more

2 registry-linked trialsOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology. Imaging cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
8.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01042379 phase2recruitingnot on this map

I-SPY Trial (Investigation of Serial Studies to Predict Your Therapeutic Response With Imaging And moLecular Analysis 2)

TypeinterventionalSponsorQuantumLeap Healthcare CollaborativeRan2010 to 2031Enrolled5,000ConditionsBreast Neoplasms, Breast Cancer, Breast Tumors, AngiosarcomaArmsStandard Therapy, AMG 386 with or without Trastuzumab, AMG 479 (Ganitumab) plus Metformin, MK-2206 with or without Trastuzumab, AMG 386 and Trastuzumab
NCT01564368 nacompletednot on this map

Diffusion Weighted MR Imaging Biomarkers for Assessment of Breast Cancer Response to Neoadjuvant Treatment: A Sub-study of the I-SPY 2 TRIAL (Investigation of Serial Studies to Predict Your Therapeutic Response With Imaging And MoLecular Analysis)

TypeinterventionalSponsorAmerican College of Radiology Imaging NetworkRan2012 to 2020Enrolled406ConditionsBreast CancerArmsdiffusion-weighted magnetic resonance imaging
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  8. The Evolution and Clinical Impact of Deep Learning Technologies in Breast MRI.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 1 institution in 1 country.

Wen LiFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).ORCID 0000-0001-6584-363X
Savannah C PartridgeFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).ORCID 0000-0001-6370-9111
David C NewittFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).ORCID 0000-0002-1735-6682
Jon SteingrimssonFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).
Helga S MarquesFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).
Patrick J BolanFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).ORCID 0000-0002-4194-3975
Michael HiranoFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).
Benjamin Aaron BearceFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).
Jayashree Kalpathy-CramerFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).ORCID 0000-0001-8906-9618
Michael A BossFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).ORCID 0000-0002-9492-767X
Xinzhi TengFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).
Jiang ZhangFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).ORCID 0000-0001-5807-1686
Jing CaiFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).
Despina KontosFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).ORCID 0000-0001-9031-5126
Eric A CohenFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).ORCID 0000-0002-5067-8835
Walter C MankowskiFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).
Michael LiuFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).
Richard HaFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).
Oscar J Pellicer-ValeroFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).
Klaus Maier-HeinFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).
Simona Rabinovici-CohenFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).
Tal TlustyFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).
Michal Ozery-FlatoFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).ORCID 0000-0002-8223-7989
Vishwa S ParekhFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).ORCID 0009-0006-2427-549X
Michael A JacobsFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).
Ran YanFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).
Kyunghyun SungFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).ORCID 0000-0003-4175-5322
Anum S KazerouniFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).ORCID 0000-0002-4200-534X
Julie C DiCarloFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).
Thomas E YankeelovFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).ORCID 0000-0001-6201-3913
Thomas L ChenevertFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).ORCID 0000-0003-1476-4274
Nola M HyltonFrom the Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, Calif (W.L., D.C.N., N.M.H.); Department of Radiology, University of Washington, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109 (S.C.P., M.H., A.S.K.); Center for Statistical Sciences, Brown University, Providence, RI (J.S., H.S.M.); Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn (P.J.B.); Athinoula A. Martinos Center for Biomedical Imaging, Harvard University, Charlestown, Mass (B.A.B., J.K.C.); Center for Research and Innovation, American College of Radiology, Philadelphia, Pa (M.A.B.); Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR (X.T., J.Z., J.C.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (D.K., E.A.C., W.C.M.); Department of Radiology, Columbia University Medical Center, New York, NY (M.L., R.H.); Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany (O.J.P.V., K.M.H.); Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany (K.M.H.); IBM Research-Israel, Haifa University Campus, Mount Carmel, Haifa, Israel (S.R.C., T.T., M.O.F.); University of Maryland Medical Intelligent Imaging (UM2ii) Center and Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (V.S.P.); The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Md (V.S.P., M.A.J.); Department of Diagnostic and Interventional Imaging, UT Health at Houston, Houston, Tex (M.A.J.); Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Calif (R.Y., K.S.); Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Calif (R.Y., K.S.); Livestrong Cancer Institutes (J.C.D., T.E.Y.), Departments of Biomedical Engineering, Diagnostic Medicine, and Oncology (T.E.Y.), and The Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Tex (J.C.D., T.E.Y.); Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex (T.E.Y.); and Department of Radiology, University of Michigan, Ann Arbor, Mich (T.L.C.).ORCID 0000-0002-6747-1662
Fred Hutch Cancer Center · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN KEITH MEEKER · 1985 to 2026
$208.6M
Project-006U10CA180820 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer · 2014 to 2026
$167.6M
IROC: Enhancing local enrolling site radiological data capture capabilities for NCTN trialsU24CA180803 · NCI · AMERICAN COLLEGE OF RADIOLOGY · PI Thomas J. FitzGerald, MICHAEL V KNOPP · 2014 to 2026
$116.2M
Statistics CoreU10CA180794 · NCI · DANA-FARBER CANCER INST · PI PAUL J CATALANO · 2014 to 2026
$111.2M
The I SPY 2.2 TRIAL: Evolving to Imaging and Molecular Biomarker Response Directed Adaptive Sequential Treatment to Optimize Breast Cancer OutcomesP01CA210961 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nola M. Hylton-Watson · 2017 to 2026
$22.9M
Elimination of Instrumental Bias for Quantitative Diffusion Imaging in Clinical Oncology TrialsR01CA190299 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MALYARENKO, DARIYA I. · 2015 to 2025
$6.4M
Multi-Modality Quantitiative Imaging for Evaluation of Response to Cancer TherapyU01CA140204 · NCI · JOHNS HOPKINS UNIVERSITY · PI DU, YONG, SOLNES, LILJA · 2011 to 2022
$6.1M
Real-time In Vivo MRI Biomarkers for Breast Cancer Pre-Operative Treatment TrialsR01CA132870 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HYLTON-WATSON, NOLA M., NEWITT, DAVID C · 2008 to 2019
$4.8M
Quantitative MRI for Predicting Response of Breast Cancer to Neoadjuvant TherapyU01CA142565 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KARCZMAR, GREGORY S., NANDA, RITA · 2010 to 2019
$4.5M
Strategy for combining circulating tumor DNA (ctDNA) and magnetic resonance imaging (MRI) measures of tumor burden for prediction of response and outcome in neoadjuvant-treated early breast cancerR01CA255442 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LI, WEN, MAGBANUA, MARK JESUS · 2021 to 2025
$3.3M
Quantitative Imaging for Assessing Breast Cancer Response to TreatmentU01CA225427 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HYLTON-WATSON, NOLA M. · 2018 to 2022
$3.2M
INTEGRATING OMICS AND QUANTITATIVE IMAGING DATA IN CO-CLINICAL TRIALS TO PREDICT TREATMENT RESPONSE IN TRIPLE NEGATIVE BREAST CANCERU24CA226110 · NCI · BAYLOR COLLEGE OF MEDICINE · PI LEWIS, MICHAEL T., RUBIN, DANIEL L · 2019 to 2023
$3.2M
NCI NIH HHS P01 CA210961NCI NIH HHS P30 CA006973NCI NIH HHS R01 CA132870NCI NIH HHS R01 CA190299NCI NIH HHS R01 CA197000NCI NIH HHS R01 CA248192NCI NIH HHS R01 CA255442NCI NIH HHS U01 CA140204NCI NIH HHS U01 CA142565NCI NIH HHS U01 CA174706NCI NIH HHS U01 CA225427NCI NIH HHS U10 CA180794NCI NIH HHS U10 CA180820NCI NIH HHS U24 CA180803NCI NIH HHS U24 CA226110NHLBI NIH HHS R01 HL149742NIBIB NIH HHS R01 EB029985NIDDK NIH HHS U01 DK127400
6 · The paper itself

Abstract

Purpose To describe the design, conduct, and results of the Breast Multiparametric MRI for prediction of neoadjuvant chemotherapy Response (BMMR2) challenge. Materials and Methods The BMMR2 computational challenge opened on May 28, 2021, and closed on December 21, 2021. The goal of the challenge was to identify image-based markers derived from multiparametric breast MRI, including diffusion-weighted imaging (DWI) and dynamic contrast-enhanced (DCE) MRI, along with clinical data for predicting pathologic complete response (pCR) following neoadjuvant treatment. Data included 573 breast MRI studies from 191 women (mean age [±SD], 48.9 years ± 10.56) in the I-SPY 2/American College of Radiology Imaging Network (ACRIN) 6698 trial (ClinicalTrials.gov: NCT01042379). The challenge cohort was split into training (60%) and test (40%) sets, with teams blinded to test set pCR outcomes. Prediction performance was evaluated by area under the receiver operating characteristic curve (AUC) and compared with the benchmark established from the ACRIN 6698 primary analysis. Results Eight teams submitted final predictions. Entries from three teams had point estimators of AUC that were higher than the benchmark performance (AUC, 0.782 [95% CI: 0.670, 0.893], with AUCs of 0.803 [95% CI: 0.702, 0.904], 0.838 [95% CI: 0.748, 0.928], and 0.840 [95% CI: 0.748, 0.932]). A variety of approaches were used, ranging from extraction of individual features to deep learning and artificial intelligence methods, incorporating DCE and DWI alone or in combination. Conclusion The BMMR2 challenge identified several models with high predictive performance, which may further expand the value of multiparametric breast MRI as an early marker of treatment response. Clinical trial registration no. NCT01042379

Indexed as

Breast NeoplasmsMultiparametric Magnetic Resonance ImagingAdultArtificial IntelligenceFemaleHumansMagnetic Resonance ImagingMiddle AgedNeoadjuvant TherapyPathologic Complete ResponseBreastMRITumor Response

Identifiers

PMID38180338
PMCPMC10825718
OpenAlexW4390617712

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