Evidence map›Paper›PMID 38180087›Full record

ArticleExperimental physiology2024

Differential splenic responses to hyperoxic breathing at high altitude in Sherpa and lowlanders.

Pontus K Holmström, Taylor S Harman, Anne Kalker, Bethany Steiner, Ella Hawkins, Kelsey C Jorgensen, Kimberly T Zhu, Ajaya J Kunwar, Nilam Thakur, Sunil Dhungel and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 4 countries.

Pontus K HolmströmDepartment of Health Sciences, Mid-Sweden University, Östersund, Sweden.ORCID 0000-0003-1957-1527
Taylor S HarmanDepartment of Anthropology, Syracuse University, Syracuse, New York, USA.
Anne KalkerDepartment of Anesthesiology, Radboud Medical Center, Nijmegen, Netherlands.
Bethany SteinerDepartment of Exercise Science, Syracuse University, Syracuse, New York, USA.
Ella HawkinsDepartment of Anthropology, Syracuse University, Syracuse, New York, USA.
Kelsey C JorgensenDepartment of Anthropology, University of California, Los Angeles, California, USA.
Kimberly T ZhuDepartment of Anthropology, University of California, Los Angeles, California, USA.
Ajaya J KunwarKathmandu Center for Genomics and Research Laboratory, Global Hospital, Gwarko, Lalitpur, Nepal.
Nilam ThakurKathmandu Center for Genomics and Research Laboratory, Global Hospital, Gwarko, Lalitpur, Nepal.
Sunil DhungelCollege of Medicine, Nepalese Army Institute of Health Sciences, Kathmandu, Nepal.
Nima SherpaLocal collaborator without institutional affiliation.
Trevor A DayDepartment of Biology, Faculty of Science and Technology, Mount Royal University, Calgary, AB, Canada.ORCID 0000-0001-7102-4235
Erika K SchagatayDepartment of Health Sciences, Mid-Sweden University, Östersund, Sweden.ORCID 0000-0001-5477-9265
Abigail W BighamDepartment of Anthropology, University of California, Los Angeles, California, USA.
Tom D BrutsaertDepartment of Exercise Science, Syracuse University, Syracuse, New York, USA.
Syracuse University · USUniversity of California, Los Angeles · USMid Sweden University · SENepalese Army Institute of Health Services · NPMount Royal University · CA

Funding

US National Science Foundation 2141893US National Science Foundation 2216548
6 · The paper itself

Abstract

The human spleen contracts in response to stress-induced catecholamine secretion, resulting in a temporary rise in haemoglobin concentration ([Hb]). Recent findings highlighted enhanced splenic response to exercise at high altitude in Sherpa, possibly due to a blunted splenic response to hypoxia. To explore the potential blunted splenic contraction in Sherpas at high altitude, we examined changes in spleen volume during hyperoxic breathing, comparing acclimatized Sherpa with acclimatized individuals of lowland ancestry. Our study included 14 non-Sherpa (7 female) residing at altitude for a mean continuous duration of 3 months and 46 Sherpa (24 female) with an average of 4 years altitude exposure. Participants underwent a hyperoxic breathing test at altitude (4300 m; barrometric pressure = ∼430 torr;

Indexed as

Altitude SicknessHyperoxiaAcclimatizationAltitudeFemaleHumansHypoxiaSpleenacclimatizationadaptationhigh altitudehypoxiaSherpaspleen function

Identifiers

PMID38180087
PMCPMC10988702
OpenAlexW4390616987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.