Evidence map›Paper›PMID 38179803›Full record

ArticleCurrent eye research2024

Factors Associated With Laboratory Test Negativity Following a Transition in Specimen Collection in Microbial Keratitis Cases.

Keith D Miller, Avi Toiv, Callie Deng, Ming-Chen Lu, Leslie M Niziol, Jenna N Hart, Eric Sherman, Shahzad I Mian, Paul R Lephart, Alan Sugar and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current eye research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Keith D MillerDepartment of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI, USA.
Avi ToivDepartment of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI, USA.
Callie DengDepartment of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI, USA.
Ming-Chen LuDepartment of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI, USA.
Leslie M NiziolDepartment of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI, USA.
Jenna N HartDepartment of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI, USA.
Eric ShermanDepartment of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0001-7500-4661
Shahzad I MianDepartment of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI, USA.
Paul R LephartDepartment of Pathology, University of Michigan Medicine, Ann Arbor, MI, USA.
Alan SugarDepartment of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI, USA.
Linda KangDepartment of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI, USA.
Maria A WoodwardDepartment of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0001-7060-9004

Funding

Quantifying Microbial Keratitis to Predict Outcomes: An Imaging and Epidemiologic ApproachR01EY031033 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WOODWARD, MARIA ANNEKE · 2020 to 2023
$1.8M
NEI NIH HHS R01 EY031033
6 · The paper itself

Abstract

purposeNegative laboratory results make targeting microbial keratitis treatment difficult. We investigated factors associated with laboratory negativity in patients with microbial keratitis in the context of a transition to a new specimen collection method.

methodsMicrobial keratitis patients with associated laboratory tests were identified in the electronic health record of a tertiary care facility from August 2012 to April 2022. Patient demographics and laboratory results were obtained. Random sampling of 50% of charts was performed to assess the impact of the ocular history and pretreatment measures. The relationship between probability of negative laboratory results with demographics, ocular history, pretreatment measures, and utilization of a new specimen collection method (i.e. ESwab) was evaluated by multivariable logistic regression.

resultsOf 3395 microbial keratitis patients identified, 31% (

conclusionMore microbial keratitis associated laboratory tests are being taken over time. Over 60% of tests were negative by 2022. Factors associated with negative laboratory test results included pretreatment with antibiotics and specimens collected with the new collection method.

Indexed as

Corneal UlcerEye Infections, BacterialKeratitisAnti-Bacterial AgentsHumansRetrospective StudiesRisk FactorsSpecimen HandlingAnti-Bacterial Agentscorneal ulcercultureESwabmicrobial keratitis

Identifiers

PMID38179803
PMCPMC10959676

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.