Evidence map›Paper›PMID 38179340›Full record

ArticleChemical engineering and processing = Genie des procedes = Verfahrenstechnik2023

Continuous Extraction of 2-Chloroethyl isocyanate for 1-(2-chloroethyl)-3-cyclohexylurea Purification.

Jaron Mackey, Devna Grover, Gabriella Pruneda, Eva Zenk, Zoltan K Nagy

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical engineering and processing = Genie des procedes = Verfahrenstechnik, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jaron MackeyDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907.
Devna GroverDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907.
Gabriella PrunedaDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907.
Eva ZenkDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907.
Zoltan K NagyDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907.
Purdue University West Lafayette · US

Funding

Risk-based process synthesis and Industry 4.0 framework for pharmaceutical manufacturing processesU01FD006738 · FDA · PURDUE UNIVERSITY · PI NAGY, ZOLTAN KALMAN · 2019 to 2021
$3.0M
FDA HHS U01 FD006738
6 · The paper itself

Abstract

This study details the development of simulation-aided design, development, and successful operation of a continuous liquid-liquid extraction platform made with 1.5 mm tubing for the extraction of 2-chloroethyl isocyanate, an important reagent in the synthesis of cancer drugs. Preliminary solvent screening was carried out with partition coefficient calculations to determine solvents of interest. Next, batch and flow extraction experiments of 2-chloroethyl isocyanate in 2-methyl tetrahydrofuran and water were conducted to estimate extraction parameters. Following parameter estimation, experimental and model values for K

Indexed as

Continuous extractionLiquid-Liquid extractionParameter EstimationProcess intensificationSimulation-based design

Identifiers

PMID38179340
PMCPMC10765575
OpenAlexW4310266315

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.