Evidence map›Paper›PMID 38179229›Full record

ArticleMaterials today. Bio2023

3D printed strontium-doped calcium phosphate ceramic scaffold enhances early angiogenesis and promotes bone repair through the regulation of macrophage polarization.

Qiuju Miao, Xiaopeng Yang, Jingjing Diao, Huanwen Ding, Yan Wu, Xiangyang Ren, Jianbo Gao, Mengze Ma, Shenyu Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 41 citations in OpenAlex.

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  14. [Research progress on strontium modified β-tricalcium phosphate composite biomaterials with immune regulatory properties].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Qiuju MiaoThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People's Republic of China.
Xiaopeng YangThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People's Republic of China.
Jingjing DiaoSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, People's Republic of China.
Huanwen DingSchool of Medicine, South China University of Technology, Guangzhou 510006, People's Republic of China.
Yan WuThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People's Republic of China.
Xiangyang RenThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People's Republic of China.
Jianbo GaoThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People's Republic of China.
Mengze MaThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People's Republic of China.
Shenyu YangThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People's Republic of China.
First Affiliated Hospital of Zhengzhou University · CNSouth China University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The vascularization of bone repair materials is one of the key issues that urgently need to be addressed in the process of bone repair. The changes in macrophage phenotype and function play an important role in the process of vascularization, and endowing bone repair materials with immune regulatory characteristics to enhance angiogenesis is undoubtedly a new strategy to improve the effectiveness of bone repair. In order to improve the effect of tricalcium phosphate (TCP) on vascularization and bone repair, we doped strontium ions (Sr) into TCP (SrTCP) and prepared porous 3D printed SrTCP scaffolds using 3D printing technology, and studied the scaffold mediated macrophage polarization and subsequent vascularization and bone regeneration. The results of the interaction between the scaffold and macrophages showed that the SrTCP scaffold can promote the polarization of macrophages from M1 to M2 and secrete high concentrations of VEGF and PDGF-bb cytokines, which shows excellent angiogenic potential. When human umbilical vein endothelial cells (HUVECs) were co-cultured with macrophage-conditioned medium of SrTCP scaffold, HUVECs exhibited excellent early angiogenesis-promoting effects in terms of scratch healing, angiogenic gene expression, and in vitro tube formation performance. The results of in vivo bone repair experiments showed that the SrTCP scaffold formed a vascular network with high density and quantity in the bone defect area, which could increase the rate of new bone formation and advance the period of bone formation, and finally achieved a better bone repair effect. We observed a cascade effect in which Sr-doped SrTCP scaffold regulate macrophage polarization to enhance angiogenesis and promote bone repair, which may provide a new strategy for the repair of clinical bone defects.

Indexed as

3D printingBone repairEarly angiogenesisMacrophage polarizationStrontium-doped calcium phosphate

Identifiers

PMID38179229
PMCPMC10765239
OpenAlexW4388805061

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.