Evidence map›Paper›PMID 38179205›Full record

ArticleFrontiers in cellular neuroscience2023

Combined RhoA morpholino and ChABC treatment protects identified lamprey neurons from retrograde apoptosis after spinal cord injury.

Jianli Hu, Guixin Zhang, William Rodemer, Li-Qing Jin, Michael E Selzer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jianli HuCenter for Neural Repair and Rehabilitation (Shriners Hospitals Pediatric Research Center), Lewis Katz School of Medicine (LKSOM) at Temple University, Philadelphia, PA, United States.
Guixin ZhangCenter for Neural Repair and Rehabilitation (Shriners Hospitals Pediatric Research Center), Lewis Katz School of Medicine (LKSOM) at Temple University, Philadelphia, PA, United States.
William RodemerCenter for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Li-Qing JinCenter for Neural Repair and Rehabilitation (Shriners Hospitals Pediatric Research Center), Lewis Katz School of Medicine (LKSOM) at Temple University, Philadelphia, PA, United States.
Michael E SelzerCenter for Neural Repair and Rehabilitation (Shriners Hospitals Pediatric Research Center), Lewis Katz School of Medicine (LKSOM) at Temple University, Philadelphia, PA, United States.
Temple University Hospital · USInstitute for Neurodegenerative Disorders · USPhiladelphia University · US

Funding

Role of Local Protein Synthesis in CNS Axon RegenerationR01NS097846 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI SELZER, MICHAEL EDGAR · 2017 to 2021
$1.8M
CSPG-induced retrograde cell death and inhibition of regeneration after SCIR01NS092876 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI SELZER, MICHAEL EDGAR · 2016 to 2020
$1.7M
NINDS NIH HHS R01 NS092876NINDS NIH HHS R01 NS097846
6 · The paper itself

Abstract

Previously, we reported that RhoA knockdown by morpholino antisense oligonucleotides (MOs), and enzymatic digestion of chondroitin sulfate proteoglycans (CSPGs) at the site of injury with chondroitinase ABC (ChABC), each can reduce retrograde neuronal apoptosis after spinal cord transection in the lamprey. To elucidate the mechanisms in neuronal survival and axon regeneration, we have investigated whether these two effects are additive

Indexed as

Aktaxon regenerationcaspasesChABClampreyneuronal apoptosisRhoASCI

Identifiers

PMID38179205
PMCPMC10764559
OpenAlexW4390056235

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.