Evidence map›Paper›PMID 38179192›Full record

ArticleRSC chemical biology2024

A unique binding mode of P1' Leu-containing target sequences for

Brandon A Vogel, Jadon M Blount, Hanna M Kodama, Noah J Goodwin-Rice, Devin J Andaluz, Sophie N Jackson, John M Antos, Jeanine F Amacher

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Amino acid variants at the P94 position inbioRxiv : the preprint server for biology · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Brandon A VogelDepartment of Chemistry, Western Washington University, 516 High St - MS9150 Bellingham WA 98225 USA antosj@wwu.edu amachej@wwu.edu +1-360-650-2826 +1-360-650-2271 +1-360-650-4397.
Jadon M BlountDepartment of Chemistry, Western Washington University, 516 High St - MS9150 Bellingham WA 98225 USA antosj@wwu.edu amachej@wwu.edu +1-360-650-2826 +1-360-650-2271 +1-360-650-4397.
Hanna M KodamaDepartment of Chemistry, Western Washington University, 516 High St - MS9150 Bellingham WA 98225 USA antosj@wwu.edu amachej@wwu.edu +1-360-650-2826 +1-360-650-2271 +1-360-650-4397.
Noah J Goodwin-RiceDepartment of Chemistry, Western Washington University, 516 High St - MS9150 Bellingham WA 98225 USA antosj@wwu.edu amachej@wwu.edu +1-360-650-2826 +1-360-650-2271 +1-360-650-4397.
Devin J AndaluzDepartment of Chemistry, Western Washington University, 516 High St - MS9150 Bellingham WA 98225 USA antosj@wwu.edu amachej@wwu.edu +1-360-650-2826 +1-360-650-2271 +1-360-650-4397.
Sophie N JacksonDepartment of Chemistry, Western Washington University, 516 High St - MS9150 Bellingham WA 98225 USA antosj@wwu.edu amachej@wwu.edu +1-360-650-2826 +1-360-650-2271 +1-360-650-4397.
John M AntosDepartment of Chemistry, Western Washington University, 516 High St - MS9150 Bellingham WA 98225 USA antosj@wwu.edu amachej@wwu.edu +1-360-650-2826 +1-360-650-2271 +1-360-650-4397.
Jeanine F AmacherDepartment of Chemistry, Western Washington University, 516 High St - MS9150 Bellingham WA 98225 USA antosj@wwu.edu amachej@wwu.edu +1-360-650-2826 +1-360-650-2271 +1-360-650-4397.ORCID https://orcid.org/0000-0002-3646-7521
Western Washington University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sortase enzymes are cysteine transpeptidases that attach environmental sensors, toxins, and other proteins to the cell surface in Gram-positive bacteria. The recognition motif for many sortases is the cell wall sorting signal (CWSS), LPXTG, where X = any amino acid. Recent work from ourselves and others has described recognition of additional amino acids at a number of positions in the CWSS, specifically at the Thr (or P1) and Gly (or P1') positions. In addition, although standard cleavage occurs between these two residues (P1/P1'), we previously observed that the SrtA enzyme from

Identifiers

PMID38179192
PMCPMC10763551
OpenAlexW4387757873

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.