Evidence map›Paper›PMID 38179104›Full record

ArticleOpen forum infectious diseases2024

Everything but the Kitchen Sink: An Analysis of Bacterial and Chemical Contaminants Found in Syringe Residue From People Who Inject Drugs.

John A Wildenthal, Drew J Schwartz, Nathanial S Nolan, Lingxia Zhao, John I Robinson, Erin Jones, Raagini Jawa, Jeffrey P Henderson, Laura R Marks

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Emergence of Infective Endocarditis Due toOpen forum infectious diseases · 2025
    Article
  4. Article
  5. Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

John A WildenthalMedical Scientist Training Program, Washington University in St Louis School of Medicine, St Louis, Missouri, USA.
Drew J SchwartzDepartment of Pediatrics, Division of Infectious Diseases, Washington University in St Louis School of Medicine, St Louis, Missouri, USA.
Nathanial S NolanDivision of Infectious Diseases, Department of Internal Medicine, Washington University in St Louis School of Medicine, St Louis, Missouri, USA.
Lingxia ZhaoDepartment of Molecular Microbiology, Washington University in St Louis School of Medicine, St Louis, Missouri, USA.
John I RobinsonDepartment of Molecular Microbiology, Washington University in St Louis School of Medicine, St Louis, Missouri, USA.
Erin JonesDepartment of Molecular Microbiology, Washington University in St Louis School of Medicine, St Louis, Missouri, USA.
Raagini JawaCenter for Research on Healthcare, Division of General Internal Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Jeffrey P HendersonDepartment of Molecular Microbiology, Washington University in St Louis School of Medicine, St Louis, Missouri, USA.
Laura R MarksDivision of Infectious Diseases, Department of Internal Medicine, Washington University in St Louis School of Medicine, St Louis, Missouri, USA.ORCID https://orcid.org/0000-0002-5317-443X

Funding

University of Pittsburgh Collaboration in Addiction Training Scholars (PittCATS) ProgramK12DA050607 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jane M. Liebschutz, Erin L Winstanley · 2020 to 2026
$3.2M
Metabolomic Signatures of Urologic Chronic Pelvic Pain SyndromeR01DK125860 · NIDDK · WASHINGTON UNIVERSITY · PI HENDERSON, JEFFREY P · 2021 to 2025
$2.8M
Antibiotic disruption of the gut microbiome and immune response in neonatal late-onset sepsisK08AI159384 · NIAID · WASHINGTON UNIVERSITY · PI SCHWARTZ, DREW JOEL · 2021 to 2025
$785k
Doris Duke Charitable Foundation 2021081NIAID NIH HHS K08 AI159384NIDA NIH HHS K12 DA050607NIDDK NIH HHS R01 DK125860
6 · The paper itself

Abstract

Background: People who inject drugs (PWID) are at high risk of severe wounds, invasive infections, and overdoses. To date, there are few data on the bacterial and chemical contaminants PWID are exposed to when using illicitly manufactured fentanyls and stimulants. Methods: Previously used injection drug use equipment was recovered in St Louis, Missouri, by harm reduction organizations over a 12-month period. Syringe residue was analyzed for bacterial contaminants by routine culturing followed by whole genome sequencing of single bacterial isolates. Chemical adulterants in syringe residue were identified by liquid chromatography-mass spectrometry. Results: Bacteria were cultured from 58.75% of 160 syringes analyzed. Polymicrobial growth was common and was observed in 23.75% of samples. Conclusions: Analysis of syringe residue from discarded drug use equipment demonstrates both chemical and biological contaminants, including medically important pathogens and adulterants.

Indexed as

Bacillus cereusfentanylinjection drug useStaphylococcus aureusxylazine

Identifiers

PMID38179104
PMCPMC10766411

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.