Evidence map›Paper›PMID 38179063›Full record

ArticleiScience2024

Epigenetic and transcriptional responses in circulating leukocytes are associated with future decompensation during SARS-CoV-2 infection.

Micah T McClain, Ilya Zhbannikov, Lisa L Satterwhite, Ricardo Henao, Nicholas S Giroux, Shengli Ding, Thomas W Burke, Ephraim L Tsalik, Christina Nix, Jorge Prado Balcazar and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Micah T McClainDivision of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA.
Ilya ZhbannikovDepartment of Medicine, Clinical Research Unit, Duke University Medical Center, Durham, NC 27710, USA.
Lisa L SatterwhiteDepartment of Civil and Environmental Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA.
Ricardo HenaoDepartment of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC 27710, USA.
Nicholas S GirouxDepartment of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA.
Shengli DingDepartment of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA.
Thomas W BurkeDivision of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA.
Ephraim L TsalikDanaher Diagnostics, Washington, DC 20037, USA.
Christina NixDivision of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA.
Jorge Prado BalcazarDepartment of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA.
Elizabeth A PetzoldDivision of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA.
Xiling ShenTerasaki Institute for Biological Innovation, Los Angeles, CA 90024, USA.
Christopher W WoodsDivision of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA.
Duke University · USDuke Medical Center · USDanaher (United States) · USTerasaki Foundation · US

Funding

Antibacterial Resistance Leadership Group (ARLG)UM1AI104681 · NIAID · DUKE UNIVERSITY · PI Vance G. Fowler, Henry F HENRY CHAMBERS · 2013 to 2026
$180.8M
NIAID VIROLOGY QUALITY ASSURANCE (VQA) COVID-1975N93019C00015 · NIAID · DUKE UNIVERSITY · PI DENNY, THOMAS · 2019 to 2025
$24.4M
Regional Biocontainment Laboratory (RBL)UC6AI058607 · NIAID · DUKE UNIVERSITY · PI WILLIAMS, R SANDERS · 2003 to 2005
$16.3M
Plasma Protein Biomarker-Based Diagnostics Of Outcome In Sepsis and CAPU01AI066569 · NIAID · NATIONAL CENTER FOR GENOME RESOURCES · PI KINGSMORE, STEPHEN FRANCIS · 2005 to 2010
$2.9M
NIAID NIH HHS 75N93019C00015NIAID NIH HHS U01 AI066569NIAID NIH HHS UC6 AI058607NIAID NIH HHS UM1 AI104681
6 · The paper itself

Abstract

To elucidate host response elements that define impending decompensation during SARS-CoV-2 infection, we enrolled subjects hospitalized with COVID-19 who were matched for disease severity and comorbidities at the time of admission. We performed combined single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase-accessible chromatin using sequencing (scATAC-seq) on peripheral blood mononuclear cells (PBMCs) at admission and compared subjects who improved from their moderate disease with those who later clinically decompensated and required invasive mechanical ventilation or died. Chromatin accessibility and transcriptomic immune profiles were markedly altered between the two groups, with strong signals in CD4

Indexed as

Components of the immune systemEpigeneticsHealth sciencesImmune responseMolecular mechanism of gene regulationTranscriptomicsVirology

Identifiers

PMID38179063
PMCPMC10765013
OpenAlexW4389152074

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.