Evidence map›Paper›PMID 38178911›Full record

ReviewFrontiers in pediatrics2023

An overview on viral interference during SARS-CoV-2 pandemic.

Luigi Matera, Sara Manti, Laura Petrarca, Alessandra Pierangeli, Maria Giulia Conti, Enrica Mancino, Salvatore Leonardi, Fabio Midulla, Raffaella Nenna

Abstract readReview
In one paragraph

Review in Frontiers in pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
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  9. Beyond respiratory syncytial virus and rhinovirus: The other viral respiratory bandits.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2025
    Review
  10. Article
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  13. Population-level respiratory virus-virus interactions, Puerto Rico, 2013-2023.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2025
    Article
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Luigi MateraDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Sara MantiDepartment of Human and Pediatric Pathology, Pediatric Unit, G. Martino Hospital, University of Messina, Messina, Italy.
Laura PetrarcaDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Alessandra PierangeliLaboratory of Virology, Department of Molecular Medicine, Affiliated to Istituto Pasteur Italia, Sapienza University of Rome, Rome, Italy.
Maria Giulia ContiDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Enrica MancinoDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Salvatore LeonardiPediatric Respiratory Unit, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Fabio MidullaDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Raffaella NennaDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory viruses represent the most frequent cause of mortality, morbidity and high healthcare costs for emergency visits and hospitalization in the pediatric age. Respiratory viruses can circulate simultaneously and can potentially infect the same host, determining different types of interactions, the so-called viral interference. The role of viral interference has assumed great importance since December 2019, when the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) came on the scene. The aim of this narrative review is to present our perspective regarding research in respiratory virus interference and discuss recent advances on the topic because, following SARS-CoV-2 restrictions mitigation, we are experimenting the co-circulation of respiratory viruses along with SARS-CoV-2. This scenario is raising many concerns about possible virus-virus interactions, both positive and negative, and the clinical, diagnostic and therapeutic management of these coinfections. Moreover, we cannot rule out that also climatic conditions and social behaviours are involved. Thus, this situation can lead to different population epidemic dynamics, including changes in the age of the targeted population, disease course and severity, highlighting the need for prospective epidemiologic studies and mathematical modelling able to predict the timing and magnitude of epidemics caused by SARS-CoV-2/seasonal respiratory virus interactions in order to adjust better public health interventions.

Indexed as

COVID-19influenzarespiratory syncytial virusrespiratory virusesRSVSARS-CoV-2viral interference

Identifiers

PMID38178911
PMCPMC10764478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.