ArticleImmunology1987
The secondary immune response to Staphylococcus aureus vaccines in efferent popliteal lymph of sheep.
Article in Immunology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 16 citations in OpenAlex.
- Surface display of LukF-PV onFuture microbiology · 2025Article
- Comparison of hock- and footpad-injection as a prostate adenocarcinoma model in rats.BMC veterinary research · 2018Article
- Hock immunization: a humane alternative to mouse footpad injections.Journal of immunological methods · 2007Article
- Staphylococcus aureus exopolysaccharide in vivo demonstrated by immunomagnetic separation and electron microscopy.Journal of clinical microbiology · 1989Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The secondary immune response to live and killed Staphylococcus aureus vaccines was studied in efferent popliteal lymph of sheep. Animals were immunized with either live or killed S. aureus intracutaneously on the lateral hock, in an area draining into the popliteal lymph node. Six weeks later, an efferent popliteal lymphatic vessel in the vaccinated leg was cannulated, and 48 hr after surgery a second inoculation (identical to the primary) was placed in the skin adjacent to the primary vaccination lesion. A dramatic decrease in lymphocyte output ('cell shutdown') was observed in lymph collected from sheep given the secondary inoculation of live S. aureus during the first 8 hr after inoculation. However, only a moderate decrease in lymphocyte output occurred in lymph from animals receiving killed S. aureus or from control animals. The proportion of eosinophils in lymph collected from animals given live S. aureus increased to a peak (14% of total leucocytes in lymph) between 6 hr and 8 hr, and returned to prechallenge levels by 24 hr post-inoculation. The percentage of neutrophils in lymph peaked between 8 hr and 1 day after injection of live bacteria. This granulocyte response was not observed in animals given killed S. aureus or control animals. IgM-, IgG1- and IgG2- containing cells (-cc) in lymph were quantified by indirect immunofluorescence. Animals given live S. aureus produced lymph with greater numbers of Ig-cc of these isotypes than those given killed organisms. The ratio of IgG2-cc:IgG1-cc was significantly greater in lymph from animals given live S. aureus from Day 2 to Day 6 post-challenge. IgM and IgG1 anti-staphylococcal antibody levels increased in lymph collected from all vaccinated animals, but only sheep given live S. aureus showed any increase in levels of IgG2 antibody.
Indexed as
Identifiers
3817874PMC1453233W123774762What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.