Evidence map›Paper›PMID 38178712›Full record

ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2024

The role of cognitive reserve and clinical symptoms in the association between genetic liability for educational attainment and functioning in first-episode psychosis: A mediation analysis.

Derek Clougher, Àlex G Segura, Maria F Forte, Gisela Mezquida, Manuel J Cuesta, Eduard Vieta, Silvia Amoretti, Antonio Lobo, Ana González-Pinto, Covadonga M Díaz-Caneja and 13 more

Abstract read
In one paragraph

Article in European psychiatry : the journal of the Association of European Psychiatrists, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Protective Effects of Genetic Proxies of Cognitive Reserve in Parkinson's Disease: A Longitudinal Multi-Cohort Study.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  4. Article
  5. European Psychiatry: 2024 in review.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Derek ClougherBipolar and Depressive Disorders Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, IDIBAPS, University of Barcelona, Barcelona, Spain.ORCID 0000-0001-7631-3845
Àlex G SeguraBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain.ORCID 0000-0002-9398-2183
Maria F ForteBipolar and Depressive Disorders Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, IDIBAPS, University of Barcelona, Barcelona, Spain.ORCID 0000-0001-5930-5501
Gisela MezquidaBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain.ORCID 0000-0002-6080-2203
Manuel J CuestaDepartment of Psychiatry, Complejo Hospitalario de Navarra, Pamplona, Spain.ORCID 0000-0003-0250-5718
Eduard VietaBipolar and Depressive Disorders Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, IDIBAPS, University of Barcelona, Barcelona, Spain.ORCID 0000-0002-0548-0053
Silvia AmorettiBipolar and Depressive Disorders Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, IDIBAPS, University of Barcelona, Barcelona, Spain.ORCID 0000-0001-6017-2734
Antonio LoboBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain.ORCID 0000-0002-9098-655X
Ana González-PintoBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain.
Covadonga M Díaz-CanejaBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain.ORCID 0000-0001-8538-3175
Alexandra RoldánBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain.
Giovanna FicoBipolar and Depressive Disorders Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, IDIBAPS, University of Barcelona, Barcelona, Spain.ORCID 0000-0003-1785-7126
Elena de la SernaBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain.ORCID 0000-0002-7869-9881
Daniel BergéBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain.ORCID 0000-0003-2544-1016
Patricia GassóBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain.ORCID 0000-0001-6930-3454
Natalia RodriguezBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain.ORCID 0000-0002-9618-9383
Norma VerdoliniLocal Health Unit Umbria 1, Department of Mental Health, Mental Health Center of Perugia, Perugia, Italy.ORCID 0000-0001-9488-2881
Alfonso TortorellaSection of Psychiatry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.ORCID 0000-0002-8095-2305
Giulia MenculiniSection of Psychiatry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.ORCID 0000-0001-8380-1943
Marta RibasésBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain.
Miguel BernardoBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain.ORCID 0000-0001-8748-6717
Sergi MasBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain.ORCID 0000-0003-3336-6298
PEPs Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPolygenic risk scores for educational attainment (PRS

methodsA total of 162 FEP patients underwent clinical, functional, and genetic assessments. Using genome-wide association study summary results, PRS

resultsA serial mediation model revealed a causal chain for PRS

conclusionsBoth CR and NS mediate the relationship between PRS

Indexed as

Cognitive ReserveEducational StatusPsychotic DisordersAdolescentAdultFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMediation AnalysisMultifactorial InheritanceYoung Adultcognitive reservefirst-episode psychosisfunctioningnegative symptomspolygenic risk score

Identifiers

PMID38178712
PMCPMC11795430

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.