Evidence map›Paper›PMID 38178671›Full record

ArticleCurrent diabetes reviews2024

Insulin Therapy on Bone Macroscopic, Microarchitecture, and MechanicalProperties of Tibia in Diabetic Rats.

Pedro Henrique Justino Oliveira Limirio, Nilson Ferreira De Oliveira Neto, Jessyca Figueira Venâncio, Camila Rodrigues Borges Linhares, Priscilla Barbosa Ferreira Soares, Paula Dechichi

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Article in Current diabetes reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pedro Henrique Justino Oliveira LimirioDepartamento de Periodontia e Implantodontia, Integrated Dental Clinic Program, School of Dentistry, University of Uberlândia, Avenida Pará s/nº, Campus Umuarama, Bloco 4L, Uberlândia, Minas Gerais,38.400-902, Brazil.ORCID 0000-0002-0089-3772
Nilson Ferreira De Oliveira NetoDepartamento de histologia, Integrated Dental Clinic Program, School of Dentistry, University of Uberlândia, Avenida Pará 1720, Campus Umuarama, Bloco 2B, Bairro Umuarama. Uberlândia, Minas Gerais, 38.400-902, Brazil.
Jessyca Figueira VenâncioDepartamento de histologia, Integrated Dental Clinic Program, School of Dentistry, University of Uberlândia, Avenida Pará 1720, Campus Umuarama, Bloco 2B, Bairro Umuarama. Uberlândia, Minas Gerais, 38.400-902, Brazil.
Camila Rodrigues Borges LinharesDepartamento de histologia, Integrated Dental Clinic Program, School of Dentistry, University of Uberlândia, Avenida Pará 1720, Campus Umuarama, Bloco 2B, Bairro Umuarama. Uberlândia, Minas Gerais, 38.400-902, Brazil.
Priscilla Barbosa Ferreira SoaresDepartment of Periodontology and Implantology, University of Uberlândia. Avenida Pará 1720, Campus Umuarama, Bloco 4L, Bairro Umuarama, Uberlândia, Minas Gerais, 38.400-902, Brazil.
Paula DechichiDepartamento de histologia, Biomedical Science Institute, University of Uberlândia, Avenida Pará 1720, Campus Umuarama, Bloco 2B, Bairro Umuarama,Uberlândia, Minas Gerais, 38.400-902, Brazil.

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação de Amparo à Pesquisa do Estado de Minas Gerais
6 · The paper itself

Abstract

backgroundThis study evaluated tibia's macroscopic structure, mechanical properties, and bone microarchitecture in rats with type 1 diabetes mellitus (T1DM).

methodsEighteen animals were divided into three groups (n=6): Non-diabetic (ND), diabetic (D), and diabetic+insulin (DI). T1DM was induced by streptozotocin; insulin was administered daily (4IU). The animals were euthanized 35 days after induction. The tibiae were removed and analyzed using macroscopic, micro-computed tomography (micro-CT) and three-point bending. The macroscopic analysis measured proximal-distal length (PD), antero-posterior thickness (AP) of proximal (AP-P) and distal (AP-D) epiphysis, and lateral-medial thickness (LM) of proximal (LM-P) and distal (LM-D) epiphysis. Micro-CT analysis closed porosity, tissue mineral density, and cortical thickness. The three-point bending test measured maximum strength, energy, and stiffness.

resultsThe macroscopic analysis showed that D presented smaller measures of length and thickness (AP and AP-P) than ND and DI. More extensive measurements were observed of LM and AP-D thickness in DI than in D. In micro-CT, DI showed larger cortical thickness than D. Mechanical analysis showed lower strength in D than in other groups.

conclusionsT1DM reduces bone growth and mechanical strength. Insulin therapy in diabetic rats improved bone growth and fracture resistance, making diabetic bone similar to normoglycemic animals.

Indexed as

Bone DensityDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Hypoglycemic AgentsInsulinTibiaX-Ray MicrotomographyAnimalsBiomechanical PhenomenaMaleRatsRats, WistarHypoglycemic AgentsInsulinbiomechanical phenomenabone growthDiabetes mellitusinsulinmicro-computed tomography.tibia

Identifiers

PMID38178671

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.