ArticleJournal of translational medicine2024
Risk factors for carotid plaque formation in type 2 diabetes mellitus.
Article in Journal of translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Long-term effects of different hypoglycemic drugs on carotid intima-media thickness progression: a systematic review and network meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Carotid plaque burden across the glycaemic spectrum: a cross-sectional study.BMC endocrine disorders · 2026Article
- Development and validation of a machine learning-based predictive model for carotid plaque in type 2 diabetes.Frontiers in cardiovascular medicine · 2026Article
- Mendelian Randomization Study on Serum Metabolites and Diabetic Nephropathy Risk: Identifying Potential Biomarkers for Early Intervention.Current pharmaceutical design · 2026Article
- Ambulatory Systolic Blood Pressure and Carotid Atherosclerosis in Type 2 Diabetes: A Critical Role of Glycemic Control Stratification.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Machine Learning Applied to CT Radiomics Identifies Symptomatic Carotid Plaques.Current medical imaging · 2026Article
- Association Between the Uric Acid to High-Density Lipoprotein Ratio and Carotid Atherosclerosis in Patients with T2DM.Current medical science · 2025Article
- Triglyceride-glucose index in diabetic chronic complications in patients with type 2 diabetes mellitus.BMC endocrine disorders · 2025Article
- Predicting carotid plaques in metabolic dysfunction-associated steatotic liver disease using machine learning and SHAP interpretation.Scientific reports · 2025Article
- Article
- Comprehensive analysis of risk factors associated with carotid plaque in patients with type 2 diabetes mellitus.World journal of diabetes · 2025Article
- [Nomogram prediction model for factors associated with vascular plaques in a physical examination population].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- Prognostic value of microRNA-495-3p, adiponectin, and cardiometabolic index in type 2 diabetic nephropathy.World journal of diabetes · 2025Article
- Lipoprotein(a) Concentration and Cardiovascular Disease in a Group of Patients With Familial Hypercholesterolemia-A Lipid Clinic Experience.Clinical cardiology · 2025Article
- Association between weight-adjusted waist index and carotid atherosclerotic plaque in patients with type 2 diabetes in the Chinese population.Diabetology & metabolic syndrome · 2025Article
- Multi-feature integrated machine learning prediction model for early nephropathy in elderly living with type 2 diabetes mellitus.Frontiers in endocrinology · 2025Article
- Lipoprotein(a) as a Risk Factor for Recurrent Ischemic Stroke in Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Development and Validation of a Nomogram for Predicting Carotid Atherosclerosis in Non-Obese Patients with Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Association between lipoprotein(a) and coronary heart disease risk in type 2 diabetes mellitus and evaluation of statin treatment effects.Revista da Associacao Medica Brasileira (1992) · 2025Article
- Potassium inwardly-rectifying channel subfamily J member 11 (KCNJ11) gene polymorphism in Egyptian type 2 diabetic patients: a single-center study.Molecular biology reports · 2024Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectPatients with type 2 diabetes mellitus (T2DM) are at higher risk of developing atherosclerosis. Previous studies have analyzed the factors associated with diabetic macrovascular disease, although whether these factors are applicable to T2DM patients with carotid atherosclerosis remains unclear. Therefore, the aim of this study was to investigate the risk factors for the formation of carotid atherosclerotic plaque in hospitalized T2DM patients and to provide a theoretical basis for early prevention and treatment of carotid atherosclerosis in these patients.
methodsA total of 949 patients with T2DM were included in the study. Carotid ultrasound identified 531 patients with carotid atherosclerotic plaque. The waist-to-hip ratio (WHR), blood glucose, liver and kidney function, blood lipid profile, islet function, and other indicators were measured at the same time to identify the risk factors and predictive significance of T2DM carotid plaque.
resultsThe proportions of men, diabetes nephropathy (DN) and hypertension in T2DM patients with carotid plaque are higher than those without carotid plaque(P < 0.05). Age, duration of diabetes, WHR, Postprandial glucose (PPG), lipoprotein (a) [Lip (a)], carcinoembryonic antigen(CEA) and estimated glomerular filtration rate (eGFR) in T2DM patients with carotid plaque were higher than those without plaque (P < 0.05). Age, WHR, duration of diabetes, hypertension, males, and Lip (a) were independent risk factors for T2DM patients with carotid plaque. Age, WHR, duration of diabetes, and Lip (a) had a higher AUC to predict T2DM with carotid artery plaque (AUC: 0.750, 0.640, 0.678, 0.552 respectively; P all < 0.001). After constructing the logit (P) value of the above risk factors, the area under the ROC curve was 0.816 (0.789-0.842, P < 0.001).
conclusionAge, WHR, duration of diabetes, hypertension, males, and Lip (a) levels are the main risk factors for the formation of carotid plaque in T2DM patients. Combining the above risk factors provides a better prediction of carotid plaque formation in T2DM.
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