SynthesisBMC medicine2024
Maternal pre-pregnancy body mass index and risk of preterm birth: a collaboration using large routine health datasets.
Synthesis in BMC medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- FIGO good practice recommendations on preconception care: A strategy to prevent preterm birth.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Guideline
- Maternal pre-pregnancy body mass index and risk of preterm birth: a collaboration using large routine health datasets.BMC medicine · 2024Pooled it
- Associations of Pre-Pregnancy and Prenatal Outdoor Nighttime Light, Green Space and Neighbourhood Walkability With Preterm Birth: Results From Ruian Birth Cohort Study.Paediatric and perinatal epidemiology · 2026Article
- Risk Factors Associated with Maternal Postpartum Hospital Readmission: A Systematic Review.Nursing reports (Pavia, Italy) · 2026Review
- Maternal intake of inadequate dietary folate, and low serum folate levels during pregnancy are associated with increased risk of preterm birth in rural Ethiopia: a prospective cohort study.Scientific reports · 2026Article
- Protein networks are influenced by maternal BMI and differentiate preterm birth types.Communications medicine · 2026Article
- Histidine Metabolic Pathway Modifies the Relationships Between 6:2 Cl-PFESA Exposure and Preterm Birth.Toxics · 2026Article
- Distinct modifiable risk factors and preventable burdens of preterm birth: a risk-stratified analysis of pregnancies with and without gestational diabetes mellitus.Frontiers in pediatrics · 2026Article
- Preterm Birth and Maternal Cardiovascular Risk.European cardiology · 2026Review
- The Mediating Role of Blood Metabolites in the Association between Basal Metabolic Rate and Obstetrical Disorders: A Mendelian Randomization AnalysisEndocrine, metabolic & immune disorders drug targets · 2026Article
- Early Postpartum Weight Retention in Women with Gestational Diabetes Mellitus in China: Current Status and Influencing Factors.International journal of women's health · 2026Article
- Analysis of related factors of spontaneous premature birth in pregnant women with gestational diabetes mellitus and construction of its nomogram risk prediction model.BMC pregnancy and childbirth · 2025Article
- Risk factors for spontaneous preterm birth are mediated through changes in cervical length.Communications medicine · 2025Article
- Establishment and validation of a prediction model for small vulnerable newborns: a retrospective study.Journal of global health · 2025Article
- Oral, Vaginal, and Placental Microbiota Profiles in Japanese Pregnancies with Preterm Birth and Chronic Abruption-Oligohydramnios Sequence (CAOS): A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2025Article
- Obstetric outcomes following artificial and natural cycle frozen embryo transfer in patients with and without endometriosis: a national cohort study.BMC pregnancy and childbirth · 2025Article
- Vaginal Lactobacillus crispatus in early pregnancy associates with favorable gestational outcomes in a Japanese maternal-neonatal microbiome cohort.Nature communications · 2025Article
- The effect of maternal pre-pregnancy body mass index on hypertensive disorders of pregnancy (HDP): a systematic review and dose-response meta-analysis of cohort studies involving 50 million pregnancies.EClinicalMedicine · 2025Article
- Association of Gestational Weight Trajectories With Neonatal Outcomes Among Pregnant Slum-Dwelling Women, India.Maternal & child nutrition · 2025Observational
- A critique of measurement of defective insulin secretion and insulin sensitivity as a precision approach to gestational diabetes.Diabetologia · 2025Observational
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 4 countries.
Funding
Abstract
backgroundPreterm birth (PTB) is a leading cause of child morbidity and mortality. Evidence suggests an increased risk with both maternal underweight and obesity, with some studies suggesting underweight might be a greater factor in spontaneous PTB (SPTB) and that the relationship might vary by parity. Previous studies have largely explored established body mass index (BMI) categories. Our aim was to compare associations of maternal pre-pregnancy BMI with any PTB, SPTB and medically indicated PTB (MPTB) among nulliparous and parous women across populations with differing characteristics, and to identify the optimal BMI with lowest risk for these outcomes.
methodsWe used three UK datasets, two USA datasets and one each from South Australia, Norway and Denmark, together including just under 29 million pregnancies resulting in a live birth or stillbirth after 24 completed weeks gestation. Fractional polynomial multivariable logistic regression was used to examine the relationship of maternal BMI with any PTB, SPTB and MPTB, among nulliparous and parous women separately. The results were combined using a random effects meta-analysis. The estimated BMI at which risk was lowest was calculated via differentiation and a 95% confidence interval (CI) obtained using bootstrapping.
resultsWe found non-linear associations between BMI and all three outcomes, across all datasets. The adjusted risk of any PTB and MPTB was elevated at both low and high BMIs, whereas the risk of SPTB was increased at lower levels of BMI but remained low or increased only slightly with higher BMI. In the meta-analysed data, the lowest risk of any PTB was at a BMI of 22.5 kg/m
conclusionsConsistency of findings across different populations, despite differences between them in terms of the time period covered, the BMI distribution, missing data and control for key confounders, suggests that severe under- and overweight may play a role in PTB risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.