ArticleBMC neurology2024
Monocyte to high-density lipoprotein cholesterol ratio is associated with cerebral small vessel diseases.
Article in BMC neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.
- Association between neutrophil-to-lymphocyte ratio and cerebral small vessel disease: a systematic review and meta-analysis.Frontiers in neurology · 2026Pooled it
- Circulating immune cells in cerebral small vessel disease: a systematic review.Biogerontology · 2025Pooled it
- Could the monocyte-to-high-density lipoprotein cholesterol ratio serve as a reliable marker for orthostatic hypotension in older adults? A cross-sectional study.BMC geriatrics · 2026Observational
- Residual inflammatory risk in ischemic stroke: incremental prognostic value of MHR and NPAR beyond the Essen stroke risk score.BMC neurology · 2026Article
- Age-associated chemokine receptor expression profiles in human peripheral blood monocyte subsets predict cardiovascular disease risk.Frontiers in immunology · 2026Article
- Predictive Value of MHR, PLR Combined With NLRP1 for Severity and Long-Term Prognosis in Premature Coronary Artery Disease.Immunity, inflammation and disease · 2025Article
- Construction and verification of a nomogram model for the risk of death in sepsis patients.Scientific reports · 2025Article
- Association between monocyte-to-HDL ratio and Fazekas-scaled white matter hyperintensities in migraine patients: a cross-sectional MRI-based study.Frontiers in neurology · 2025Article
- Elevated monocyte-to-high-density lipoprotein ratio is associated with increased risk of cognitive impairment and severe cerebral small vessel disease burden.Frontiers in aging neuroscience · 2025Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundInflammation is a major pathological mechanism underlying cerebrovascular disease. Recently, a new inflammatory marker based on the ratio between monocyte count and high-density lipoprotein (HDL) cholesterol has been proposed. In this study, we evaluated the relationship between monocyte-to-HDL cholesterol ratio (MHR) and cerebral small vessel disease (cSVD) lesions in health check-up participants.
methodsThis study was a retrospective cross-sectional study based on a registry that prospectively collected health check-up participants between 2006 and 2013. Three cSVD subtypes were measured on brain magnetic resonance imaging. White matter hyperintensity (WMH) volume, and lacunes and cerebral microbleeds (CMBs) were quantitatively and qualitatively measured, respectively. The MHR was calculated according to the following formula: MHR = monocyte counts (× 10
resultsIn total, 3,144 participants were evaluated (mean age: 56 years, male sex: 53.9%). In multivariable analyzes adjusting for confounders, MHR was significantly associated with WMH volume [β = 0.099, 95% confidence interval (CI) = 0.025 to 0.174], lacune [adjusted odds ratio (aOR) = 1.43, 95% CI = 1.07-1.91], and CMB (aOR = 1.51, 95% CI = 1.03-2.19). In addition, MHR showed a positive quantitative relationship with cSVD burden across all three subtypes: WMH (P < 0.001), lacunes (P < 0.001), and CMBs (P < 0.001).
conclusionsHigh MHR was closely associated with cSVD in health check-up participants. Because these associations appear across all cSVD subtypes, inflammation appears to be a major pathological mechanism in the development of various cSVDs.
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