Evidence map›Paper›PMID 38177672›Full record

ArticleNature structural & molecular biology2024

THEMIS is a substrate and allosteric activator of SHP1, playing dual roles during T cell development.

Jiali Zhang, Zhenzhou Jiang, Xueyuan Zhang, Ziqun Yang, Jinjiao Wang, Jialing Chen, Li Chen, Minfang Song, Yanchun Zhang, Mei Huang and 12 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature structural & molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Structural and Biochemical Analysis of the CABIT1 Domain of THEMIS.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. THEMIS promotes T cell development and maintenance by rising the signaling threshold of the inhibitory receptor BTLA.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 3 institutions in 1 country.

Jiali Zhang *School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Zhenzhou Jiang *School of Life Science and Technology, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0000-0002-0241-7323
Xueyuan ZhangSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Ziqun YangUniversity of Chinese Academy of Sciences, Beijing, China.
Jinjiao WangSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Jialing ChenSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Li ChenSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Minfang SongSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Yanchun ZhangSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Mei HuangSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Shengmiao ChenSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Xuexue XiongSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Yuetong WangSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Piliang HaoSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Tiffany HorngSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0000-0002-9265-4559
Min ZhuangSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0000-0001-6215-5807
Liye ZhangSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Erwei ZuoInstitute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0001-8259-0275
Fang BaiSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0000-0003-1468-5568
Jie ZhengUniversity of Chinese Academy of Sciences, Beijing, China.
Haopeng WangSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China. wanghp@shanghaitech.edu.cn.ORCID http://orcid.org/0000-0002-4995-0838
Gaofeng FanSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China. fangf@shanghaitech.edu.cn.ORCID http://orcid.org/0000-0002-6729-2867
ShanghaiTech University · CNChinese Academy of Sciences · CNShanghai Institute of Materia Medica · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

THEMIS plays an indispensable role in T cells, but its mechanism of action has remained highly controversial. Using the systematic proximity labeling methodology PEPSI, we identify THEMIS as an uncharacterized substrate for the phosphatase SHP1. Saturated mutagenesis assays and mass spectrometry analysis reveal that phosphorylation of THEMIS at the evolutionally conserved Tyr34 residue is oppositely regulated by SHP1 and the kinase LCK. Similar to THEMIS

Indexed as

Intercellular Signaling Peptides and ProteinsThymocytesAnimalsMiceMice, KnockoutReceptors, Antigen, T-CellSignal TransductionIntercellular Signaling Peptides and ProteinsReceptors, Antigen, T-Cell

Identifiers

PMID38177672
OpenAlexW4390582066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.