Evidence map›Paper›PMID 38177669›Full record

ArticleNature structural & molecular biology2024

Structural basis for partial agonism in 5-HT

Kevin Felt, Madeleine Stauffer, Leslie Salas-Estrada, Peter R Guzzo, Dejian Xie, Jinkun Huang, Marta Filizola, Sudha Chakrapani

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Nature structural & molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Asymmetric gating of a homopentameric ion channel GLIC revealed by cryo-EM.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kevin FeltDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-1832-747X
Madeleine Stauffer *Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-0595-2276
Leslie Salas-Estrada *Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Peter R GuzzoSciMount Therapeutics (Shenzhen) Co. Ltd., Shenzhen, China.ORCID http://orcid.org/0009-0007-4773-8052
Dejian XieSciMount Therapeutics (Shenzhen) Co. Ltd., Shenzhen, China.
Jinkun HuangSciMount Therapeutics (Shenzhen) Co. Ltd., Shenzhen, China.
Marta FilizolaDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-4382-8276
Sudha ChakrapaniDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA. Sudha.chakrapani@case.edu.ORCID http://orcid.org/0000-0003-0722-2338
Case Western Reserve University · USIcahn School of Medicine at Mount Sinai · US

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7M
Structure and Function of Pentameric Ligand-Gated Ion ChannelsR35GM134896 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI Sudha Chakrapani · 2020 to 2026
$4.7M
Acquisition of 200kV Glacios Cryo Transmission Electron MicroscopeS10OD032437 · OD · CASE WESTERN RESERVE UNIVERSITY · PI CHAKRAPANI, SUDHA · 2022 to 2022
$2.0M
COVID and Translational Science supercomputer (CATS)S10OD030463 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2021 to 2021
$2.0M
Big Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M
STRUCTURE, FUNCTION, AND MODULATION OF SERORTONIN (3A) RECEPTORSR01GM131216 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI CHAKRAPANI, SUDHA · 2019 to 2019
$442k
NCATS NIH HHS UL1 TR004419NEI NIH HHS P30 EY011373NIGMS NIH HHS R01 GM131216NIGMS NIH HHS R35 GM134896NIH HHS S10 OD026880NIH HHS S10 OD030463NIH HHS S10 OD032437
6 · The paper itself

Abstract

Hyperactivity of serotonin 3 receptors (5-HT

Indexed as

Antineoplastic AgentsIrritable Bowel SyndromeAnimalsMiceNauseaSerotoninVomitingAntineoplastic AgentsSerotonin

Identifiers

PMID38177669
PMCPMC12631364
OpenAlexW4390581964

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.