ArticleEMBO molecular medicine2024
Versican accumulation drives Nos2 induction and aortic disease in Marfan syndrome via Akt activation.
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Article in EMBO molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17citing papers in PubMed
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Who cites it
17 citing papers in PubMed, 13 citations in OpenAlex.
- Regulation of Inducible Nitric Oxide Synthase (NOS2) Expression in Healthy and Inflamed Bowel: A Narrative Review.International journal of molecular sciences · 2026Review
- The aorta in Marfan syndrome: from molecular mechanisms to mechanobiological dysfunction.Cardiovascular research · 2026Review
- Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Fibronectin-induced overactivation of αNature communications · 2026Article
- Mechanotransduction in Marfan Syndrome and Related Aortic Disorders: Insights from Transcriptomic Analyses.Genes · 2026Review
- Versican regulating viscoelasticity drives pleural fibrosis via mechanotransductive signaling.JCI insight · 2026Article
- Chromobox 3 assembles an epigenetic complex contributing to cystathionine γ-lyase-mediated protection against aortic aneurysm/dissection.Nature communications · 2026Article
- Structural and Signaling Mechanisms of Aortic Wall Failure in Heritable Thoracic Aortic Disease.Cells · 2026Review
- VCAN Is Essential for ERK5-Driven Tumorigenesis in Soft Tissue Sarcoma.International journal of biological sciences · 2026Article
- Excessive glycosylation drives thoracic aortic aneurysm formation through integrated stress response.European heart journal · 2025Article
- Proteoglycans as Biomarkers of Medial Degeneration in Acute Stanford Type A Aortic Dissection.Reviews in cardiovascular medicine · 2025Review
- PP2Acα Deficiency in Vascular Smooth Muscle Cells Accelerates Aortic Aneurysm and Dissection by Regulating KLF4 Phosphorylation and Ubiquitination.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Extracellular matrix in vascular homeostasis and disease.Nature reviews. Cardiology · 2025Review
- ERBB4 as a therapeutic target in aortic dissection: Implications for cell-based therapies in vascular regeneration.Biomolecules & biomedicine · 2025Article
- Glycosylation-Related Genes and Prognostic Signatures in Diabetic Nephropathy.International journal of general medicine · 2025Article
- Identification of Pivotal ceRNA Networks Associated with Stanford-A Aortic Dissection via Integrated Bioinformatics Analysis.International journal of general medicine · 2025Article
- Genetic Manipulation of Caveolin-1 in a Transgenic Mouse Model of Aortic Root Aneurysm: Sex-Dependent Effects on Endothelial and Smooth Muscle Function.International journal of molecular sciences · 2024Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 2 countries.
María Jesús Ruiz-RodríguezGene Regulation in Cardiovascular Remodeling and Inflammation Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, 28029, Spain.ORCID http://orcid.org/0000-0002-9317-8646
Jorge Oller *Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
Sara Martínez-Martínez *Gene Regulation in Cardiovascular Remodeling and Inflammation Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, 28029, Spain.
Iván Alarcón-RuizGene Regulation in Cardiovascular Remodeling and Inflammation Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, 28029, Spain.ORCID http://orcid.org/0000-0002-1372-8469
Marta ToralGene Regulation in Cardiovascular Remodeling and Inflammation Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, 28029, Spain.ORCID http://orcid.org/0000-0001-5324-8569
Yilin SunCell-Cell Communication & Inflammation Unit, Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, 28049, Spain.ORCID http://orcid.org/0000-0003-2606-5593
Ángel ColmenarGene Regulation in Cardiovascular Remodeling and Inflammation Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, 28029, Spain.
María José Méndez-OlivaresGene Regulation in Cardiovascular Remodeling and Inflammation Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, 28029, Spain.ORCID http://orcid.org/0009-0008-4512-5559
Dolores López-MaderueloGene Regulation in Cardiovascular Remodeling and Inflammation Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, 28029, Spain.
Christine B KernMedical University of South Carolina (MUSC), Charleston, SC, 29425, USA.ORCID http://orcid.org/0000-0001-7955-8979
J Francisco NistalCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.ORCID http://orcid.org/0000-0002-4152-7621
Arturo EvangelistaTeknon Medical Centre-Quironsalud. Heart Institute, Barcelona, Spain.
Gisela Teixido-TuraCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.ORCID http://orcid.org/0000-0003-4714-2420
Miguel R Campanero *Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. mcampanero@cbm.csic.es.ORCID http://orcid.org/0000-0003-1410-8621
Juan Miguel Redondo *Gene Regulation in Cardiovascular Remodeling and Inflammation Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, 28029, Spain. jmredondo@cbm.csic.es.ORCID http://orcid.org/0000-0001-5779-9122
Spanish National Centre for Cardiovascular Research · ESConsejo Superior de Investigaciones Científicas · ESCentro de Investigación en Red en Enfermedades Cardiovasculares · ESHospital Quirón Teknon · ESMedical University of South Carolina · USUniversidad de Cantabria · ES
Funding
Fundació la Marató de TV3 (Fundació la Marató) 20151330Fundacion MERCK-Fundacion Espanola de Enfermedades Raras Muévete por los que no pueden 2021Instituto de Investigación Marqués de Valdecilla (IDIVAL) INNVAL 21/24'la Caixa' Foundation ('la Caixa') HR18-00068Marfan Foundation (The Marfan Foundation) MRF/1701MEC | Instituto de Salud Carlos III (ISCIII) CB16/11/00264MEC | Instituto de Salud Carlos III (ISCIII) CB16/11/00479MEC | Instituto de Salud Carlos III (ISCIII) PI17/00381MEC | Instituto de Salud Carlos III (ISCIII) PI21/00084Ministerio de Ciencia e Innovación (MCIN) BES-2016-077649Ministerio de Ciencia e Innovación (MCIN) CD18/00028Ministerio de Ciencia e Innovación (MCIN) CEX2020-001041-SMinisterio de Ciencia e Innovación (MCIN) CEX2021-001154-SMinisterio de Ciencia e Innovación (MCIN) IJC2020-044581-IMinisterio de Ciencia e Innovación (MCIN) PID2020-115217RB-100Ministerio de Ciencia e Innovación (MCIN) PID2021-122388OB-100Ministerio de Ciencia e Innovación (MCIN) RTI2018-099246-B-I00Ministerio de Ciencia e Innovación (MCIN) RYC2021-033343-IMinisterio de Universidades (MU) FPU 20/04814
Abstract
Thoracic aortic aneurysm and dissection (TAAD) is a life-threatening condition associated with Marfan syndrome (MFS), a disease caused by fibrillin-1 gene mutations. While various conditions causing TAAD exhibit aortic accumulation of the proteoglycans versican (Vcan) and aggrecan (Acan), it is unclear whether these ECM proteins are involved in aortic disease. Here, we find that Vcan, but not Acan, accumulated in Fbn1
Indexed as
Aortic Aneurysm, ThoracicAortic DiseasesAortic DissectionAzidesDeoxyglucoseMarfan SyndromeAnimalsHumansMiceNitric Oxide Synthase Type IIProto-Oncogene Proteins c-aktVersicans1,3,4,6-tetra-O-acetyl-2-azido-2-deoxyglucopyranoseAkt1 protein, mouseAzidesDeoxyglucoseNitric Oxide Synthase Type IINos2 protein, mouseProto-Oncogene Proteins c-aktVcan protein, mouseVersicansAkt; Aortic Aneurysm; Marfan Syndrome; Nos2; Versican
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