Evidence map›Paper›PMID 38177456›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2024

Initial characterization of a transgenic mouse with overexpression of the human D

Lina Maria Rayo Abella, Hannes Jacob, Christin Hesse, Britt Hofmann, Sarah Schneider, Lisa Schindler, Max Keller, Igor B Buchwalow, CongYu Jin, Pertti Panula and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Clozapine acts as an antagonist of human dopamine DNaunyn-Schmiedeberg's archives of pharmacology · 2026
    Article
  2. Initial characterization of MNaunyn-Schmiedeberg's archives of pharmacology · 2026
    Article
  3. Temperature alters the inotropic and chronotropic effect of DNaunyn-Schmiedeberg's archives of pharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 4 countries.

Lina Maria Rayo AbellaInstitute for Pharmacology and Toxicology, Medical Faculty, Martin Luther University Halle-Wittenberg, D-06097, Halle (Saale), Germany.
Hannes JacobInstitute for Pharmacology and Toxicology, Medical Faculty, Martin Luther University Halle-Wittenberg, D-06097, Halle (Saale), Germany.
Christin HesseInstitute for Pharmacology and Toxicology, Medical Faculty, Martin Luther University Halle-Wittenberg, D-06097, Halle (Saale), Germany.
Britt HofmannDepartment of Cardiac Surgery, Mid-German Heart Center, University Hospital Halle, D-06097, Halle (Saale), Germany.
Sarah SchneiderInstitute for Pharmacology and Toxicology, Medical Faculty, Martin Luther University Halle-Wittenberg, D-06097, Halle (Saale), Germany.
Lisa SchindlerInstitute of Pharmacy, University of Regensburg, D-93053, Regensburg, Germany.
Max KellerInstitute of Pharmacy, University of Regensburg, D-93053, Regensburg, Germany.
Igor B BuchwalowInstitute for Hematopathology, D-22547, Hamburg, Germany.
CongYu JinDepartment of Anatomy, University of Helsinki, FI-00290, Helsinki, Finland.
Pertti PanulaDepartment of Anatomy, University of Helsinki, FI-00290, Helsinki, Finland.
Stefan DheinRudolf-Boehm Institute for Pharmacology and Toxicology, University Leipzig, D-04107, Leipzig, Germany.
Jan KlimasDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, SK-83232, Bratislava, Slovak Republic.
Katarína HadovaDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, SK-83232, Bratislava, Slovak Republic.
Ulrich GergsInstitute for Pharmacology and Toxicology, Medical Faculty, Martin Luther University Halle-Wittenberg, D-06097, Halle (Saale), Germany.
Joachim NeumannInstitute for Pharmacology and Toxicology, Medical Faculty, Martin Luther University Halle-Wittenberg, D-06097, Halle (Saale), Germany. joachim.neumann@medizin.uni-halle.de.
Martin Luther University Halle-Wittenberg · DEComenius University Bratislava · SKUniversity of Helsinki · FIUniversity of Regensburg · DELeipzig University · DEPeoples' Friendship University of Russia · RUUniversity Hospital in Halle · DE

Funding

Deutsche Forschungsgemeinschaft 519414516
6 · The paper itself

Abstract

Dopamine can exert effects in the mammalian heart via five different dopamine receptors. There is controversy whether dopamine receptors increase contractility in the human heart. Therefore, we have generated mice that overexpress the human D

Indexed as

MyocardiumReceptors, Dopamine D12,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineAnimalsDopamineDopamine AgonistsHeartHeart AtriaHeart RateHumansMaleMiceMice, Inbred C57BLMice, TransgenicMyocardial ContractionMyocytes, Cardiac2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineDopamineDopamine AgonistsDRD1 protein, humanReceptors, Dopamine D1RNA, MessengerForce of contractionHuman D1-dopamine receptorTransgenic mouse heart

Identifiers

PMID38177456
PMCPMC11166794
OpenAlexW4390577399

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.