Evidence map›Paper›PMID 38177455›Full record

ArticleCancer causes & control : CCC2024

Benign breast disease and breast cancer risk in African women: a case-control study.

Olasubomi J Omoleye, Jincong Q Freeman, Mojisola Oluwasanu, Adenike Adeniji-Sofoluwe, Anna E Woodard, Benjamin S Aribisala, Prisca O Adejumo, Atara Ntekim, Timothy Makumbi, Paul Ndom and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

Olasubomi J OmoleyeDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Jincong Q FreemanDepartment of Public Health Sciences, University of Chicago, Chicago, IL, USA.
Mojisola OluwasanuDepartment of Health Promotion and Education, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
Adenike Adeniji-SofoluweDepartment of Radiology, University of Ibadan College of Medicine, Ibadan, Oyo State, Nigeria.
Anna E WoodardCenter for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, IL, USA.
Benjamin S AribisalaDepartment of Computer Science, Lagos State University, Ikeja, Lagos, Nigeria.
Prisca O AdejumoDepartment of Nursing, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
Atara NtekimDepartment of Radiation Oncology, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
Timothy MakumbiDepartment of Surgery, Mulago Hospital, Mulago, Kampala, Uganda.
Paul NdomHôpital Général Yaoundé, Yaoundé, Cameroon.
IkeOluwapo O AjayiDepartment of Epidemiology and Medical Statistics, University of Ibadan, Ibadan, Oyo State, Nigeria.
Olufunmilayo I OlopadeDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Dezheng HuoCenter for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, IL, USA. dhuo@bsd.uchicago.edu.
University of Ibadan · NGUniversity of Chicago · USChicago Department of Public Health · USLagos State University · NGMulago Hospital · UGYaoundé General Hospital · CM

Funding

Polygenic Risk Prediction of Breast Cancer for Women of African DescentR01CA228198 · NCI · UNIVERSITY OF CHICAGO · PI Dezheng Huo · 2018 to 2026
$3.9M
Using Genomics to Reduce Breast Cancer Disparities in the African DiasporaU01CA161032 · NCI · UNIVERSITY OF CHICAGO · PI HUO, DEZHENG, OLOPADE, OLUFUNMILAYO F. · 2012 to 2015
$3.6M
Etiology and Genomics of Breast Cancer Progression in Women of African AncestryR01MD013452 · NIMHD · UNIVERSITY OF CHICAGO · PI HUO, DEZHENG, OLOPADE, OLUFUNMILAYO F. · 2019 to 2023
$2.8M
Genetics of Breast Cancer in BlacksR01CA089085 · NCI · UNIVERSITY OF CHICAGO · PI OLOPADE, OLUFUNMILAYO F. · 2002 to 2006
$2.8M
NCI NIH HHS R01 CA089085NCI NIH HHS R01 CA228198NCI NIH HHS U01 CA161032NIH HHS R01CA089085NIH HHS U01CA161032NIMHD NIH HHS R01 MD013452Susan G. Komen Komen ScholarSusan G. Komen TREND21675016
6 · The paper itself

Abstract

purposeTo examine the association between benign breast disease (BBD) and breast cancer (BC) in a heterogeneous population of African women.

methodsBC cases and controls were enrolled in three sub-Saharan African countries, Nigeria, Cameroon, and Uganda, between 1998 and 2018. Multivariable logistic regression was used to test the association between BBD and BC. Risk factors dually associated with BBD and BC were selected. Using a parametric mediation analysis model, we assessed if selected BC risk factors were mediated by BBD.

resultsOf 6,274 participants, 55.6% (3,478) were breast cancer cases. 360 (5.7%) self-reported BBD. Fibroadenoma (46.8%) was the most commonly reported BBD. Women with a self-reported history of BBD had greater odds of developing BC than those without (adjusted odds ratio [aOR] 1.47, 95% CI 1.13-1.91). Biopsy-confirmed BBD was associated with BC (aOR 2.25, 95% CI 1.26-4.02). BBD did not significantly mediate the effects of any of the selected BC risk factors.

conclusionsIn this study, BBD was associated with BC and did not significantly mediate the effects of selected BC risk factors.

Indexed as

Breast DiseasesBreast NeoplasmsAdultAgedCameroonCase-Control StudiesFemaleHumansMiddle AgedNigeriaRisk FactorsUgandaYoung AdultAfricaBenign breast diseaseBreast cancerNigeriaRisk factors

Identifiers

PMID38177455
PMCPMC12571382
OpenAlexW4390619487

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.