Evidence map›Paper›PMID 38177313›Full record

ArticleThe EMBO journal2024

Structural insight into the allosteric inhibition of human sodium-calcium exchanger NCX1 by XIP and SEA0400.

Yanli Dong, Zhuoya Yu, Yue Li, Bo Huang, Qinru Bai, Yiwei Gao, Qihao Chen, Na Li, Lingli He, Yan Zhao

Open access · hybridAbstract read
In one paragraph

Article in The EMBO journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

  1. Sustained Ion Imbalances Enhance Ferroptosis.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. The NaThe Journal of veterinary medical science · 2026
    Review
  4. Molecular mechanisms of mitochondrial CaNature communications · 2026
    Article
  5. Article
  6. Molecular mechanisms of mitochondrial CabioRxiv : the preprint server for biology · 2026
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Inter-Organellar CaCells · 2025
    Review
  13. Article
  14. Calcium channels as pharmacological targets for cancer therapy.Clinical and experimental medicine · 2025
    Review
  15. Review
  16. Article
  17. International journal of molecular sciences · 2024
    Article
  18. Article
  19. Structural dynamics of NaCommunications biology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Yanli Dong *Key Laboratory of Biomacromolecules (CAS), National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.ORCID http://orcid.org/0000-0002-7919-3276
Zhuoya Yu *Key Laboratory of Biomacromolecules (CAS), National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Yue Li *Key Laboratory of Biomacromolecules (CAS), National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.ORCID http://orcid.org/0000-0002-1211-7383
Bo HuangBeijing StoneWise Technology Co Ltd., 15 Haidian street, Haidian district, Beijing, China.
Qinru BaiKey Laboratory of Biomacromolecules (CAS), National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Yiwei GaoKey Laboratory of Biomacromolecules (CAS), National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.ORCID http://orcid.org/0000-0001-8169-9332
Qihao ChenKey Laboratory of Biomacromolecules (CAS), National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Na LiHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Lingli HeKey Laboratory of Biomacromolecules (CAS), National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Yan ZhaoKey Laboratory of Biomacromolecules (CAS), National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. zhaoy@ibp.ac.cn.ORCID http://orcid.org/0000-0002-4348-256X
Chinese Academy of Sciences · CNBeijing Haidian Hospital · CNCapital Medical University · CNInstitute of Biophysics · CN

Funding

Chinese Academy of sciences Strategic priority Research Program XDB37030304Chinese National Programs for Brain Science and Brain-like Intelligence Technology 2022ZD0205800MOST | National Key Research and Development Program of China (NKPs) 2021YFA1301501MOST | National Natural Science Foundation of China (NSFC) 32200978MOST | National Natural Science Foundation of China (NSFC) 32301026MOST | National Natural Science Foundation of China (NSFC) 92157102the Youth Innovation Promotion Association of the Chinese Academy of Sciences 2022089
6 · The paper itself

Abstract

Sodium-calcium exchanger proteins influence calcium homeostasis in many cell types and participate in a wide range of physiological and pathological processes. Here, we elucidate the cryo-EM structure of the human Na

Indexed as

CalciumSodium-Calcium ExchangerAniline CompoundsHumansPhenyl EthersAniline CompoundsCalciumPhenyl EthersSEA 0400Sodium-Calcium Exchangersodium-calcium exchanger 1Allosteric InhibitionCalcium HomeostasisExchanger Inhibitory Peptide (XIP)SEA0400Sodium-calcium Exchanger

Identifiers

PMID38177313
PMCPMC10897212
OpenAlexW4389941113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.