ArticleCommunications biology2024
Multiple ageing effects on testicular/epididymal germ cells lead to decreased male fertility in mice.
Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Sperm DNA fragmentation and its influence on mammalian reproduction.Nature reviews. Urology · 2026Review
- Testicular SIRT1 Loss Reveals an Aging-Like Proteomic Landscape and Precipitates Reproductive Deterioration.Andrology · 2026Article
- Article
- SIRT7 links H3K36ac epigenetic regulation with genome maintenance in the mouse testis.Nature communications · 2026Article
- When sperm age, their RNA code hits a cliff.The EMBO journal · 2026Article
- Sex differences in microglia morphology and function across the lifespan are mediated by the early hormone environment.Brain, behavior, and immunity · 2026Article
- Single-cell analysis of testicular bacterial microbiome changes during aging and effect on reproductive capacity in mice.iScience · 2025Article
- Silicon-Based Agent Attenuates Age-Related Spermatogenesis Disorder.International journal of urology : official journal of the Japanese Urological Association · 2025Article
- Effects of Aging on Mammalian Spermatogenesis From a Cellular Perspective.Molecular reproduction and development · 2025Review
- Germ cells and the aging niche: a systems approach to reproductive longevity.Journal of assisted reproduction and genetics · 2025Review
- Deep-learning-based automated prediction of mouse seminiferous tubule stage by using bright-field microscopy.Scientific reports · 2025Article
- Age-related decline in behavior and reproductive health in male mice.Scientific reports · 2025Article
- Age-Dependent Clonal Expansion of Non-Sperm-Forming Spermatogonial Stem Cells in Mouse Testes.Aging cell · 2025Article
- A Single-Cell Transcriptome Atlas Characterizes the Immune Landscape of Human Testes During Aging.Aging cell · 2025Article
- Deciphering the Contribution of Circular RNAs to Age-Related Decline in Sertoli Cell Survivor.Aging cell · 2025Article
- Epididymal-Born circRNA Cargo and Its Implications in Male Fertility.International journal of molecular sciences · 2025Review
- Exploring the Mechanisms of Testicular Aging: Advances in Biomarker Research.Aging and disease · 2025Review
- Histone lysine methyltransferases and their specific methylation marks show significant changes in mouse testes from young to older ages.Biogerontology · 2025Article
- Defects in the H3t Gene Cause an Increase in Leydig Cells With Impaired Spermatogenesis in Mice.Genes to cells : devoted to molecular & cellular mechanisms · 2025Article
- Male aging in germ cells: What are we inheriting?Genetics and molecular biology · 2025Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 1 country.
Funding
Abstract
In mammals, females undergo reproductive cessation with age, whereas male fertility gradually declines but persists almost throughout life. However, the detailed effects of ageing on germ cells during and after spermatogenesis, in the testis and epididymis, respectively, remain unclear. Here we comprehensively examined the in vivo male fertility and the overall organization of the testis and epididymis with age, focusing on spermatogenesis, and sperm function and fertility, in mice. We first found that in vivo male fertility decreased with age, which is independent of mating behaviors and testosterone levels. Second, overall sperm production in aged testes was decreased; about 20% of seminiferous tubules showed abnormalities such as germ cell depletion, sperm release failure, and perturbed germ cell associations, and the remaining 80% of tubules contained lower number of germ cells because of decreased proliferation of spermatogonia. Further, the spermatozoa in aged epididymides exhibited decreased total cell numbers, abnormal morphology/structure, decreased motility, and DNA damage, resulting in low fertilizing and developmental rates. We conclude that these multiple ageing effects on germ cells lead to decreased in vivo male fertility. Our present findings are useful to better understand the basic mechanism behind the ageing effect on male fertility in mammals including humans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.