Evidence map›Paper›PMID 38177248›Full record

ArticlePediatric research2024

Association of ACE1 I/D polymorphism and susceptibility to COVID-19 in Egyptian children and adolescents.

Naglaa F Boraey, Marwa A Bebars, Ali A Wahba, Hanan M Abd El Lateef, Mohamed Atif Attia, Ahmed H Elsayed, Khalid A Rashed, Ehab I Sorour, Mohamed F Ahmed, Ghada A B Abd-Elrehim and 41 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Are COVID-19 Polymorphisms in ACE and ACE2 Prognosis Predictors?Current issues in molecular biology · 2024
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

51 authors at 14 institutions in 5 countries.

Naglaa F BoraeyDepartment of Pediatrics, Faculty of Medicine, Sohag University, Sohag, Egypt.
Marwa A BebarsDepartment of Pediatrics, Princess Alexandra hospital, Harlow, UK.
Ali A WahbaDepartment of Pediatrics at SSMC (Sheikh Shakhbout Medical City, Abu Dhabi, UAE.
Hanan M Abd El LateefDepartment of Pediatrics, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
Mohamed Atif AttiaDepartment of Pediatrics at SKMC (Sheikh khalifa Medical City, Abu Dhabi, UAE.
Ahmed H ElsayedDepartment of Pediatrics, Faculty of Medicine for Boys, Al-Azhar University, Al-Azhar, Egypt.
Khalid A RashedDepartment of Pediatrics, Faculty of Medicine for Boys, Al-Azhar University, Al-Azhar, Egypt.
Ehab I SorourDepartment of Pediatrics, Faculty of Medicine for Boys, Al-Azhar University, Al-Azhar, Egypt.
Mohamed F AhmedDepartment of Pediatrics, Faculty of Medicine for Boys, Al-Azhar University, Al-Azhar, Egypt.
Ghada A B Abd-ElrehimDepartment of Pediatrics, Faculty of Medicine, Sohag University, Sohag, Egypt.
Attia A SolimanDepartment of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Mohamed M M ShehabDepartment of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Eman M ElhindawyDepartment of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Ahmed A A IbraheemDepartment of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Hassan ShehataDepartment of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Yousif M YousifDepartment of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Mustafa I A HashemDepartment of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Amani A AhmedDepartment of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Ahmed A EmamDepartment of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt. ahmedemam1111@yahoo.com.
Dalia M GameilDepartment of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Eman M AbdelhadyDepartment of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Khalil AbdelkhalekDepartment of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.
Walaa E M A MorsiDepartment of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.
Dalia M SelimDepartment of Pediatrics, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
Suzan A RazekDepartment of Pediatrics, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
Bassem AshrafDepartment of Otorhinolaryngology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Ahmed S E SalehDepartment of Otorhinolaryngology, Faculty of Medicine, Benha University, Benha, Egypt.
Heba H EltrawyDepartment of Chest diseases, Faculty of Medicine for Girls, Al-Azhar University, Al-Azhar, Egypt.
Mohamed I AlanwarDepartment of Cardiothoracic surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Rania A FouadDepartment of Medical Biochemistry, College of Medicine, AlMaarefa University, Riyadh, Saudi Arabia.
Walaa E OmarDepartment of Medical Biochemistry, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Rehab M NabilDepartment of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Mohamed R AbdelhamedDepartment of Clinical pathology, Faculty of Medicine for Boys, Al-Azhar University, Al-Azhar, Egypt.
Mona Yousri IbrahimDepartment of Clinical pathology, Faculty of Medicine for Girls, Al-Azhar University, Al-Azhar, Egypt.
Mai M MalekDepartment of Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Mona R AfifyDepartment of Medical microbiology and Parasitology. Faculty of Medicine, University of Jeddah, Jeddah, 21589, Saudi Arabia.
Mohanned T AlharbiDepartment of Medical microbiology and Parasitology. Faculty of Medicine, University of Jeddah, Jeddah, 21589, Saudi Arabia.
Mohammed K NagshabandiDepartment of Medical microbiology and Parasitology. Faculty of Medicine, University of Jeddah, Jeddah, 21589, Saudi Arabia.
Muyassar K TarabulsiDepartment of Medical microbiology and Parasitology. Faculty of Medicine, University of Jeddah, Jeddah, 21589, Saudi Arabia.
Mohammed Esmail QashqaryDepartment of Family and community medicine, University Medical Center, University of Jeddah, Jeddah, Saudi Arabia.
Laila M AlmoraieDepartment of Family and community medicine, University Medical Center, University of Jeddah, Jeddah, Saudi Arabia.
Hanan F SalemDepartment of Anesthesia, Faculty of Medicine, Benha University, Banha, Egypt.
Manal M RashadDepartment of Anesthesia, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Sonya A A El-GaalyDepartment of Internal Medicine, Faculty of Medicine, Ain-Shams University, Ain-Shams, Egypt.
Nahawand A El-DeebDepartment of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Amany M AbdallahDepartment of Family Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Ahmed R FakhreldinDepartment of Pediatrics, Faculty of Medicine, Aswan University, Aswan, Egypt.
Mohamed HassoubaDepartment of Pediatrics, SUNY Downstate Health Science University, Kings County Hospital, Brooklyn, NY, USA.
Yasmine M MassoudDepartment of Tropical Medicine, Faculty of Medicine, Ain-Shams University, Ain-Shams, Egypt.
Mona S M AttayaDepartment of Pediatrics, Faculty of Medicine for Girls, Al-Azhar University, Al-Azhar, Egypt.
Mohammed K HaridiDepartment of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
Zagazig University · EGAl-Azhar University · EGJeddah University · SAAin Shams University · EGBenha University · EGCairo University · EGSohag University · EGAssiut University · EGAswan University · EGKings County Hospital Center · USMansoura University · EGPrincess Alexandra Hospital NHS Trust · GBShaikh Khalifa Medical City · AESheikh Shakhbout Medical City · AE

Funding

The Egyptian Knowledge Bank (EKB)The Science, Technology & Innovation Funding Authority (STDF)
6 · The paper itself

Abstract

backgroundGiven the sparse data on the renin-angiotensin system (RAS) and its biological effector molecules ACE1 and ACE2 in pediatric COVID-19 cases, we investigated whether the ACE1 insertion/deletion (I/D) polymorphism could be a genetic marker for susceptibility to COVID-19 in Egyptian children and adolescents.

methodsThis was a case-control study included four hundred sixty patients diagnosed with COVID-19, and 460 well-matched healthy control children and adolescents. The I/D polymorphism (rs1799752) in the ACE1 gene was genotyped by polymerase chain reaction (PCR), meanwhile the ACE serum concentrations were assessed by ELISA.

resultsThe ACE1 D/D genotype and Deletion allele were significantly more represented in patients with COVID-19 compared to the control group (55% vs. 28%; OR = 2.4; [95% CI: 1.46-3.95]; for the DD genotype; P = 0.002) and (68% vs. 52.5%; OR: 1.93; [95% CI: 1.49-2.5] for the D allele; P = 0.032). The presence of ACE1 D/D genotype was an independent risk factor for severe COVID-19 among studied patients (adjusted OR: 2.6; [95% CI: 1.6-9.7]; P < 0.001.

conclusionsThe ACE1 insertion/deletion polymorphism may confer susceptibility to SARS-CoV-2 infection in Egyptian children and adolescents. IMPACT: Recent studies suggested a crucial role of renin-angiotensin system and its biological effector molecules ACE1 and ACE2 in the pathogenesis and progression of COVID-19. To our knowledge, ours is the first study to investigate the association of ACE1 I/D polymorphism and susceptibility to COVID-19 in Caucasian children and adolescents. The presence of the ACE1 D/D genotype or ACE1 Deletion allele may confer susceptibility to SARS-CoV-2 infection and being associated with higher ACE serum levels; may constitute independent risk factors for severe COVID-19. The ACE1 I/D genotyping help design further clinical trials reconsidering RAS-pathway antagonists to achieve more efficient targeted therapies.

Indexed as

COVID-19Genetic Predisposition to DiseasePeptidyl-Dipeptidase APolymorphism, GeneticSARS-CoV-2AdolescentAllelesCase-Control StudiesChildChild, PreschoolEgyptFemaleGene FrequencyGenotypeHumansINDEL MutationACE protein, humanPeptidyl-Dipeptidase A

Identifiers

PMID38177248
PMCPMC11521986
OpenAlexW4390580742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.