Evidence map›Paper›PMID 38177212›Full record

ArticleScientific reports2024

mRNA vaccination of rabbits alters the fecundity, but not the attachment, of adult Ixodes scapularis.

Jaqueline Matias, Yingjun Cui, Geoffrey E Lynn, Kathleen DePonte, Emily Mesquita, Hiromi Muramatsu, Mohamad G Alameh, Garima Dwivedi, Ying K Tam, Norbert Pardi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Immunization with mRNA-LNPs EncodingPathogens (Basel, Switzerland) · 2025
    Article
  3. Borrelia surface proteins: new horizons in Lyme disease diagnosis.Applied microbiology and biotechnology · 2025
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jaqueline MatiasSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, 06520, USA. jaqmatias@hotmail.com.
Yingjun CuiSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, 06520, USA.
Geoffrey E LynnSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, 06520, USA.
Kathleen DePonteSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, 06520, USA.
Emily MesquitaSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, 06520, USA.
Hiromi MuramatsuDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Mohamad G AlamehDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Garima DwivediDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ying K TamAcuitas Therapeutics, Vancouver, BC, V6T 1Z3, Canada.
Norbert PardiDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Drew WeissmanDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Erol FikrigSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, 06520, USA. erol.fikrig@yale.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Tick Resources CoreP01AI138949 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI Erol Fikrig · 2018 to 2026
$13.5M
A novel Lyme disease vaccineR01AI165499 · NIAID · YALE UNIVERSITY · PI CRAFT, JOSEPH EDGAR, FIKRIG, EROL · 2022 to 2025
$3.2M
NCATS NIH HHS UL1 TR001863NIAID NIH HHS P01 AI138949NIAID NIH HHS R01 AI165499NIH HHS AI165499
6 · The paper itself

Abstract

19ISP is a nucleoside-modified mRNA-lipid nanoparticle vaccine that targets 19 Ixodes scapularis proteins. We demonstrate that adult I. scapularis have impaired fecundity when allowed to engorge on 19ISP-immunized rabbits. 19ISP, therefore, has the potential to interrupt the tick reproductive cycle, without triggering some of the other effects associated with acquired tick resistance. This may lead to the development of new strategies to reduce I. scapularis populations in endemic areas.

Indexed as

IxodesAnimalsFertilityRabbitsRNA, MessengerVaccinationRNA, Messenger

Identifiers

PMID38177212
PMCPMC10766947

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.