ArticleNature communications2024
De novo biosynthesis of the hops bioactive flavonoid xanthohumol in yeast.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 53 citations in OpenAlex.
- Yeast species resource exploration and application in cell factories.Synthetic and systems biotechnology · 2026Review
- Metabolic Engineering Strategies for Flavonoid Biosynthesis in Saccharomyces cerevisiae: Current Advances and Future Perspectives.Biotechnology and bioengineering · 2026Review
- In situ sol-gel-sol transformation formed by sodium alginate realizes folic acid-modified chitosan nanoparticles to deliver hops β-acids for colorectal cancer therapy.Journal of nanobiotechnology · 2026Article
- Engineering peroxisomal cofactor systems in Saccharomyces cerevisiae for enhanced biosynthesis of α-humulene.World journal of microbiology & biotechnology · 2026Article
- Association mapping for hop cone chemistry and morphology identifies natural beneficial allele stacks.The plant genome · 2026Article
- Microbial production of xanthohumol driven by synthetic biology approaches.World journal of microbiology & biotechnology · 2026Review
- De novo biosynthesis of alpinetin enhanced by directed evolution of 5-O-methyltransferase.Microbial cell factories · 2026Article
- Improvement of enfumafungin production by Hormonema carpetanum via mutagenesis and process optimization: mutant generation and preliminary transcriptomic analysis.World journal of microbiology & biotechnology · 2026Article
- Tuning aromatic cage occupancy in prenyltransferases enables selective and efficient production of rare c-prenylated flavonoids.Nature communications · 2026Article
- A flavin-dependent monooxygenase favors the formation of (6S)-α-bitter acids in hop glandular trichomes.Plant communications · 2026Article
- DyeDactic workflow to predict halochromism of biosynthetic colourants.Communications chemistry · 2026Article
- Engineering robustSynthetic and systems biotechnology · 2025Article
- Engineering yeast peroxisome assembly enables the increased production of acetyl-CoA and its derived 5-deoxyflavonoids.Nature communications · 2025Article
- Engineering chronological lifespan toward a robust yeast cell factory.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Recent Advances in Biosynthesis Technology and Future Functional Foods.Foods (Basel, Switzerland) · 2025Article
- Article
- Impact ofMolecules (Basel, Switzerland) · 2025Article
- A Review of the Progress in the Microbial Biosynthesis of Prenylated Aromatic Compounds.Molecules (Basel, Switzerland) · 2025Review
- De novo biosynthesis of taxifolin in yeast peroxisomes.Microbial cell factories · 2025Article
- Reverse prenylation in plants by non-canonical aromatic prenyltransferases.The Plant journal : for cell and molecular biology · 2025Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The flavonoid xanthohumol is an important flavor substance in the brewing industry that has a wide variety of bioactivities. However, its unstable structure results in its low content in beer. Microbial biosynthesis is considered a sustainable and economically viable alternative. Here, we harness the yeast Saccharomyces cerevisiae for the de novo biosynthesis of xanthohumol from glucose by balancing the three parallel biosynthetic pathways, prenyltransferase engineering, enhancing precursor supply, constructing enzyme fusion, and peroxisomal engineering. These strategies improve the production of the key xanthohumol precursor demethylxanthohumol (DMX) by 83-fold and achieve the de novo biosynthesis of xanthohumol in yeast. We also reveal that prenylation is the key limiting step in DMX biosynthesis and develop tailored metabolic regulation strategies to enhance the DMAPP availability and prenylation efficiency. Our work provides feasible approaches for systematically engineering yeast cell factories for the de novo biosynthesis of complex natural products.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.