Evidence map›Paper›PMID 38176731›Full record

ArticleAJNR. American journal of neuroradiology2024

Clinical and Imaging Findings in Children with Myelin Oligodendrocyte Glycoprotein Antibody Associated Disease (MOGAD): From Presentation to Relapse.

Elizabeth George, Jeffrey B Russ, Alexandria Validrighi, Heather Early, Mark D Mamlouk, Orit A Glenn, Carla M Francisco, Emmanuelle Waubant, Camilla Lindan, Yi Li

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Movement Disorders in MOGAD: A Systematic Review.Medicina (Kaunas, Lithuania) · 2026
    Pooled it
  2. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Elizabeth GeorgeFrom the Department of Radiology and Biomedical Imaging (E.G., O.A.G., C.L., Y.L.), University of California San Francisco, San Francisco, California Elizabeth.george@ucsf.edu.ORCID 0000-0003-3141-5738
Jeffrey B RussDepartment of Pediatrics (J.B.R.), Division of Neurology, Duke University, Durham, North Carolina.ORCID 0000-0001-8781-686X
Alexandria ValidrighiDivision of Child Neurology (A.V.), Department of Neurology, University of California San Francisco, San Francisco, California.ORCID 0000-0001-5596-3275
Heather EarlyDepartment of Radiology (H.E.), University of Texas Southwestern, Dallas, Texas.
Mark D MamloukPermanente Medical Group (M.D.M.), Kaiser Permanente Medical Center Santa Clara, Santa Clara, California.ORCID 0000-0002-6689-8912
Orit A GlennFrom the Department of Radiology and Biomedical Imaging (E.G., O.A.G., C.L., Y.L.), University of California San Francisco, San Francisco, California.ORCID 0000-0002-4642-1252
Carla M FranciscoDepartment of Neurology (C.M.F., E.W.), University of California San Francisco, San Francisco, California.ORCID 0000-0002-4628-3064
Emmanuelle WaubantDepartment of Neurology (C.M.F., E.W.), University of California San Francisco, San Francisco, California.
Camilla LindanFrom the Department of Radiology and Biomedical Imaging (E.G., O.A.G., C.L., Y.L.), University of California San Francisco, San Francisco, California.ORCID 0000-0001-6514-2315
Yi LiFrom the Department of Radiology and Biomedical Imaging (E.G., O.A.G., C.L., Y.L.), University of California San Francisco, San Francisco, California.ORCID 0000-0001-8535-2168
University of California, San Francisco · USDuke University · USKaiser Permanente Santa Clara Medical Center · USThe University of Texas Southwestern Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeMyelin oligodendrocyte glycoprotein-antibody associated disease (MOGAD) is an increasingly recognized cause of demyelinating disease in children. The purpose of this study is to characterize the CNS imaging manifestations of pediatric MOGAD and identify clinical and imaging variables associated with relapse. MATERIALS AND

methodsWe retrospectively identified children with serum antibody-positive MOGAD evaluated at our institution between 1997 and 2020. Clinical and demographic data were collected. MRIs of the brain, orbit, and spine at presentation and relapse were reviewed for location and pattern of abnormality.

resultsAmong 61 cases (34 girls), mean age at presentation was 7 years (IQR 4-11). At presentation, there was imaging involvement of the brain in 78.6% (44/56), optic pathway in 55.4% (31/56), and spine in 19.6% (11/56). Brain involvement was commonly in the frontal (70.5%, 31/44) and subcortical (75%, 33/44) white matter, with involvement of the thalamus and pons in 47.7% each (21/44). Optic neuritis (ON) was commonly bilateral (80.6%, 25/31) involving intraorbital segments (77.4%, 24/31). Spinal cord lesions were typically cervical (72.7%, 8/11) and multifocal (72.7%, 8/11).The imaging patterns were age-dependent; children ≤9 years more commonly demonstrated ADEM-like imaging pattern at presentation (39.4%, 13/33) and first relapse (8/23, 34.8%), while children >9 years more commonly had ON at presentation (34.8%, 8/23,

conclusionsWe describe the CNS imaging findings in pediatric MOGAD. The imaging pattern is age-dependent at presentation and first relapse. Younger age at presentation is associated with longer time to relapse.

Indexed as

EncephalitisOptic NeuritisAutoantibodiesBrainChildChild, PreschoolChronic DiseaseFemaleHumansMyelin-Oligodendrocyte GlycoproteinRetrospective StudiesAutoantibodiesMyelin-Oligodendrocyte Glycoprotein

Identifiers

PMID38176731
PMCPMC11285982
OpenAlexW4390631707

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.