Evidence map›Paper›PMID 38176326›Full record

Trial reportAddictive behaviors2024

A reduction in cigarette smoking improves health-related quality of life and does not worsen psychiatric symptoms in individuals with serious mental illness.

Daniel J Brady, Peter L Phalen, Daniel J O Roche, Tovah Cowan, Melanie E Bennett

Open access · greenAbstract readClinical Trial
In one paragraph

Trial report in Addictive behaviors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Daniel J BradyMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, 55 Wade Ave, Catonsville, MD 21228, United States.
Peter L PhalenDivision of Psychiatric Services Research, Department of Psychiatry, University of Maryland School of Medicine, 737 West Lombard Street, Baltimore, MD 21201, United States.
Daniel J O RocheMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, 55 Wade Ave, Catonsville, MD 21228, United States.
Tovah CowanDivision of Psychiatric Services Research, Department of Psychiatry, University of Maryland School of Medicine, 737 West Lombard Street, Baltimore, MD 21201, United States.
Melanie E BennettDivision of Psychiatric Services Research, Department of Psychiatry, University of Maryland School of Medicine, 737 West Lombard Street, Baltimore, MD 21201, United States. Electronic address: mbennett@som.umaryland.edu.
University of Maryland, Baltimore · US

Funding

Development of minocycline as a neuroimmune therapy for alcohol use disorderK01AA026005 · NIAAA · UNIVERSITY OF MARYLAND BALTIMORE · PI ROCHE, DANIEL · 2017 to 2021
$925k
Targeting Emotion Dysregulation to Reduce Suicide in People with PsychosisK23MH125024 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI PHALEN, PETER LEE · 2022 to 2025
$711k
NIAAA NIH HHS K01 AA026005NIMH NIH HHS K23 MH125024
6 · The paper itself

Abstract

introductionIndividuals with serious mental illness (SMI) smoke cigarettes at a much higher rate than the general population, increasing their risk for medical illnesses and mortality. However, individuals with SMI do not get enough support to quit smoking, partially because of concerns from medical providers that reducing smoking may worsen their symptoms or quality of life.

methodsVeterans with SMI and nicotine dependence (n = 178) completed a 12-week smoking cessation trial (parent trial dates: 2010-2014) including assessments of smoking status, psychiatric symptoms (Brief Psychiatric Rating Scale), and quality of life (Lehman Quality of Life Interview-Short Version) at up to four time points: baseline, post-treatment, three-month follow-up, and 9-month follow-up. Bayesian multilevel modeling estimated the impact of changes in the self-reported number of cigarettes per day in the past seven days on psychiatric symptoms and quality of life.

resultsBetween subjects, each additional pack of cigarettes smoked per day was associated with a 0.83 point higher score (95%CI: 0.03 to 1.7) on a negative symptoms scale ranging from 0 to 35. Within subjects, each one-pack reduction in the number of cigarettes smoked per day was associated with an improvement of 0.32 (95%CI = 0.12 to 0.54) on the health-related quality of life scale, which ranges from 0 to 7 points. There were no other significant between- or within-subjects effects of smoking on psychiatric symptoms or quality of life.

conclusionsIndividuals with SMI and their providers should pursue smoking cessation without fear of worsening psychiatric symptoms or quality of life.

Indexed as

Cigarette SmokingMental DisordersBayes TheoremHumansQuality of LifeSmokingPsychiatric symptomsQuality of lifeSchizophreniaSelf-medication hypothesisSerious mental illnessSmoking

Identifiers

PMID38176326
PMCPMC10863476
OpenAlexW4390226894

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.