Evidence map›Paper›PMID 38176024›Full record

ArticleJournal of the American Chemical Society2024

Visualizing the Interface of Biotin and Fatty Acid Biosynthesis through SuFEx Probes.

Aochiu Chen, Rebecca N Re, Tony D Davis, Kelley Tran, Yuta W Moriuchi, Sitong Wu, James J La Clair, Gordon V Louie, Marianne E Bowman, David J Clarke and 4 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. RSC chemical biology · 2026
    Article
  2. bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Aochiu ChenDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, San Diego, California 92093, United States.
Rebecca N ReDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, San Diego, California 92093, United States.ORCID 0000-0001-7004-4971
Tony D DavisDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, San Diego, California 92093, United States.
Kelley TranDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, San Diego, California 92093, United States.
Yuta W MoriuchiDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, San Diego, California 92093, United States.ORCID 0000-0002-8797-8014
Sitong WuDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, San Diego, California 92093, United States.ORCID 0000-0002-7984-784X
James J La ClairDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, San Diego, California 92093, United States.
Gordon V LouieJack H. Skirball Center for Chemical Biology and Proteomics, Salk Institute for Biological Studies, La Jolla, San Diego, California 92037, United States.
Marianne E BowmanJack H. Skirball Center for Chemical Biology and Proteomics, Salk Institute for Biological Studies, La Jolla, San Diego, California 92037, United States.
David J ClarkeEaSTCHEM School of Chemistry, University of Edinburgh, Joseph Black Building, David Brewster Rd, Edinburgh EH9 3FJ, U.K.ORCID 0000-0002-3741-2952
C Logan MackayEaSTCHEM School of Chemistry, University of Edinburgh, Joseph Black Building, David Brewster Rd, Edinburgh EH9 3FJ, U.K.ORCID 0000-0003-1018-8353
Dominic J CampopianoEaSTCHEM School of Chemistry, University of Edinburgh, Joseph Black Building, David Brewster Rd, Edinburgh EH9 3FJ, U.K.ORCID 0000-0001-8573-6735
Joseph P NoelJack H. Skirball Center for Chemical Biology and Proteomics, Salk Institute for Biological Studies, La Jolla, San Diego, California 92037, United States.ORCID 0000-0002-1277-0331
Michael D BurkartDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, San Diego, California 92093, United States.ORCID 0000-0002-4472-2254
University of California San Diego · USSalk Institute for Biological Studies · USUniversity of Edinburgh · GB

Funding

UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
Protein-Protein Interactions in Natural Product BiosynthesisR01GM095970 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BURKART, MICHAEL D. · 2012 to 2025
$5.9M
Interrogation of Microbial Natural Product MethyltransferasesR00GM129454 · NIGMS · STATE UNIVERSITY OF NY,BINGHAMTON · PI DAVIS, TONY D. · 2021 to 2023
$747k
Domain adaptation approaches to unify established and emerging sequencing technologiesK99HG012945 · NHGRI · UNIVERSITY OF COLORADO DENVER · PI DAVIDSON, NATALIE ROSE · 2023 to 2024
$201k
Capturing the key protein and substrate interactions in polyketide synthases using isosteric mimeticsF31GM139327 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RE, REBECCA N. · 2020 to 2022
$117k
Interrogation of Microbial Natural Product MethyltransferasesK99GM129454 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAVIS, TONY D. · 2019 to 2019
$93k
NHGRI NIH HHS K99 HG012945NIGMS NIH HHS F31 GM139327NIGMS NIH HHS K12 GM068524NIGMS NIH HHS K99 GM129454NIGMS NIH HHS R00 GM129454NIGMS NIH HHS R01 GM095970
6 · The paper itself

Abstract

Site-specific covalent conjugation offers a powerful tool to identify and understand protein-protein interactions. In this study, we discover that sulfur fluoride exchange (SuFEx) warheads effectively crosslink the

Indexed as

BiotinFluoridesSulfur CompoundsTandem Mass SpectrometryEscherichia coliFatty AcidsBiotinFatty AcidsFluoridesSulfur Compoundssulfur fluoride

Identifiers

PMID38176024
PMCPMC12332981
OpenAlexW4390574488

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.