Evidence map›Paper›PMID 38175961›Full record

ArticleThe Journal of experimental medicine2024

Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children.

Paul Bastard, Adrian Gervais, Maki Taniguchi, Liisa Saare, Karita Särekannu, Tom Le Voyer, Quentin Philippot, Jérémie Rosain, Lucy Bizien, Takaki Asano and 80 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of experimental medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
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  4. High risk of hypoxemic COVID-19 pneumonia in myasthenia gravis patients with type I IFN autoantibodies.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  12. iScience · 2025
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

90 authors at 20 institutions in 19 countries.

Paul BastardLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.ORCID 0000-0002-5926-8437
Adrian Gervais *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.ORCID 0000-0002-1083-5787
Maki Taniguchi *Dept. of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.ORCID 0009-0005-4035-1360
Liisa Saare *Dept. of Pediatrics, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.ORCID 0000-0003-1991-4120
Karita Särekannu *Molecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.ORCID 0000-0002-5984-668X
Tom Le Voyer *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.ORCID 0000-0002-7253-3135
Quentin Philippot *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.ORCID 0000-0003-3429-9605
Jérémie Rosain *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.ORCID 0000-0002-2822-161X
Lucy Bizien *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.ORCID 0000-0001-9163-9122
Takaki Asano *Dept. of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.ORCID 0000-0003-1424-2433
Marina Garcia-Prat *Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB) , Barcelona, Spain.ORCID 0000-0001-5387-1908
Alba Parra-Martínez *Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB) , Barcelona, Spain.ORCID 0000-0002-9564-8912
Mélanie Migaud *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.ORCID 0000-0003-3062-1214
Miyuki TsumuraDept. of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.ORCID 0000-0002-8272-9588
Francesca ContiPediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna , Bologna, Italy.ORCID 0000-0002-3665-8926
Alexandre BelotNational Reference Center for Rheumatic, and Autoimmune and Systemic Diseases in Children , Lyon, France.ORCID 0000-0003-4902-5332
Jacques G RivièrePediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB) , Barcelona, Spain.ORCID 0000-0003-1055-2063
Tomohiro MorioDept. of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.ORCID 0000-0002-9259-1025
Junko TanakaDept. of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.ORCID 0000-0002-5669-4051
Etienne JavouheyPediatric Intensive Care Unit, Hospices Civils de Lyon, Hopital Femme Mère Enfant , Lyon, France.ORCID 0000-0002-6480-0758
Filomeen HaerynckDept. of Paediatric Immunology and Pulmonology, Center for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Center, Ghent University Hospital, Ghent, Belgium.ORCID 0000-0001-9161-7361
Sotirija DuvlisFaculty of Medical Sciences, University "Goce Delchev" , Stip, Republic of Northern Macedonia.ORCID 0000-0001-8587-7386
Tayfun OzcelikDept. of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey.ORCID 0000-0001-5937-1082
Sevgi KelesMeram Medical Faculty, Necmettin Erbakan University , Konya, Turkey.ORCID 0000-0001-7344-8947
Yacine Tandjaoui-LambiottePulmonology and Infectious Disease Department, Saint Denis Hospital, Saint Denis, France.ORCID 0000-0003-1123-4788
Simon EscodaPediatric Dept., Saint-Denis Hospital, Saint-Denis, France.ORCID 0000-0001-9328-1945
Maya HusainPediatric Dept., Saint-Denis Hospital, Saint-Denis, France.ORCID 0000-0001-7704-9628
Qiang Pan-HammarströmDivision of Immunology, Dept. of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-1990-8804
Lennart HammarströmDivision of Immunology, Dept. of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-8635-9609
Gloria AhlijahLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.ORCID 0000-0001-9017-3113
Anthony Abi HaidarLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.ORCID 0009-0001-8555-7988
Camille SoudeeLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.ORCID 0009-0002-1445-7223
Vincent ArseguelLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.
Hassan AbolhassaniDivision of Immunology, Dept. of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-4838-0407
Sabina SahanicDept. of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0002-0583-9310
Ivan TancevskiDept. of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0001-5116-8960
Yoko NukuiDept. of Infection Control and Prevention, Medical Hospital, TMDU, Tokyo, Japan.ORCID 0000-0002-6123-5212
Seiichi HayakawaDept. of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.ORCID 0000-0002-2833-2010
George P ChrousosUniversity Research Institute of Maternal and Child Health and Precision Medicine, National and Kapodistrian University of Athens , Athens, Greece.ORCID 0000-0002-3098-5264
Athanasios MichosUniversity Research Institute of Maternal and Child Health and Precision Medicine, National and Kapodistrian University of Athens , Athens, Greece.ORCID 0000-0003-1745-1118
Elizabeth-Barbara TatsiUniversity Research Institute of Maternal and Child Health and Precision Medicine, National and Kapodistrian University of Athens , Athens, Greece.ORCID 0000-0001-7325-6195
Filippos FilippatosUniversity Research Institute of Maternal and Child Health and Precision Medicine, National and Kapodistrian University of Athens , Athens, Greece.ORCID 0000-0003-2775-3670
Agusti Rodriguez-PalmeroNeurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat , Barcelona, Spain.ORCID 0000-0002-4141-5515
Jesus TroyaDept. of Internal Medicine, Infanta Leonor University Hospital, Madrid, Spain.ORCID 0000-0001-7323-114X
Imran TipuUniversity of Management and Technology , Lahore, Pakistan.ORCID 0000-0002-9317-9729
Isabelle MeytsDept. of Immunology, Laboratory of Inborn Errors of Immunity, Microbiology and Transplantation, KU Leuven, Leuven, Belgium.ORCID 0000-0003-1214-0302
Lucie RousselDept. of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, Canada.ORCID 0000-0001-5355-702X
Sisse Rye OstrowskiDept. of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.ORCID 0000-0001-5288-3851
Laire SchidlowskiFaculdades Pequeno Príncipe, Instituto de Pesquisa Pelé Pequeno Príncipe , Curitiba, Brazil.ORCID 0000-0002-0452-0164
Carolina PrandoFaculdades Pequeno Príncipe, Instituto de Pesquisa Pelé Pequeno Príncipe , Curitiba, Brazil.ORCID 0000-0002-9570-9770
Antonio Condino-NetoDept. of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.ORCID 0000-0002-1069-3117
Nathalie CheikhPediatric Hematology Unit, University Hospital of Besançon , Besançon, France.ORCID 0000-0002-3403-3842
Ahmed A BousfihaDept. of Pediatric Infectious Disease and Clinical Immunology, CHU Ibn Rushd and LICIA, Laboratoire d'Immunologie Clinique, Inflammation et Allergie, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.ORCID 0000-0002-5011-9873
Jalila El BakkouriLaboratory of Immunology, CHU Ibn Rushd and LICIA, Laboratoire d'Immunologie Clinique, Inflammation et Allergie, Faculty of Medicine and Pharmacy, Hassan II University , Casablanca, Morocco.ORCID 0000-0003-2303-3369
COVID Clinicians
GEN-COVID Study Group
COVID Human Genetic Effort
Pärt PetersonMolecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.ORCID 0000-0001-6755-791X
Aurora PujolNeurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies , Barcelona, Spain.ORCID 0000-0002-9606-0600
Romain LévyLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.ORCID 0000-0002-6393-0198
Pierre QuartierUniversity Paris Cité, Imagine Institute , Paris, France.ORCID 0000-0002-1769-549X
Donald C VinhDept. of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, Canada.ORCID 0000-0003-1347-7767
Bertrand BoissonLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.ORCID 0000-0001-5240-3555
Vivien BéziatLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.ORCID 0000-0002-4020-824X
Shen-Ying ZhangLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.ORCID 0000-0002-9449-3672
Alessandro BorghesiNeonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo , Pavia, Italy.ORCID 0000-0002-8773-9144
Andrea PessionPediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna , Bologna, Italy.ORCID 0000-0002-0379-9562
Evangelos AndreakosCenter for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens , Athens, Greece.ORCID 0000-0001-5536-1661
Nico MarrResearch Branch, Sidra Medicine , Doha, Qatar.ORCID 0000-0002-1927-7072
Alexios-Fotios A MentisUniversity Research Institute of Maternal and Child Health and Precision Medicine, National and Kapodistrian University of Athens , Athens, Greece.ORCID 0000-0002-1480-390X
Trine H MogensenDept. of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark.ORCID 0000-0002-1853-9704
Carlos Rodríguez-GallegoHospital Universitario de Gran Canaria Dr Negrín, Canarian Health System , Las Palmas, Spain.ORCID 0000-0002-4344-8644
Pere Soler-PalacinPediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB) , Barcelona, Spain.ORCID 0000-0002-0346-5570
Roger ColobranImmunology Division, Genetics Dept., Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, UAB, Barcelona, Spain.ORCID 0000-0002-5964-536X
Vallo TillmannDept. of Pediatrics, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.ORCID 0000-0002-5279-4493
Bénédicte NevenUniversity Paris Cité, Imagine Institute , Paris, France.ORCID 0000-0001-8941-0935
Sophie Trouillet-AssantHospices Civils de Lyon , Lyon, France.ORCID 0000-0001-6439-4705
Petter BrodinUnit for Clinical Pediatrics, Dept. of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.ORCID 0000-0002-8103-0046
Laurent Abel *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.ORCID 0000-0001-7016-6493
Emmanuelle Jouanguy *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.ORCID 0000-0002-7358-9157
Qian Zhang *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.ORCID 0000-0002-9040-3289
Federico Martinón-Torres *Translational Pediatrics and Infectious Diseases, Pediatrics Dept., Hospital Clínico Universitario de Santiago, Servizo Galego de Saude (SERGAS), Santiago de Compostela, Spain.ORCID 0000-0002-9023-581X
Antonio Salas *Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III , Madrid, Spain.ORCID 0000-0002-2336-702X
Alberto Gómez-Carballa *GENVIP Research Group, Instituto de Investigación Sanitaria de Santiago (IDIS), Universidad de Santiago de Compostela , Galicia, Spain.ORCID 0000-0003-0927-1272
Luis I Gonzalez-Granado *Immunodeficiencies Unit, Hospital 12 de octubre, Research Institute Hospital 12 octubre , Madrid, Spain.ORCID 0000-0001-6917-8980
Kai Kisand *Molecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.ORCID 0000-0002-5426-4648
Satoshi Okada *Dept. of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.ORCID 0000-0002-4622-5657
Anne Puel *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.ORCID 0000-0003-2603-0323
Aurélie Cobat *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.ORCID 0000-0001-7209-6257
Jean-Laurent Casanova *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children , Paris, France.ORCID 0000-0002-7782-4169
Inserm · FRUniversidade de Santiago de Compostela · ESHiroshima University · JPInstitut des Maladies Génétiques Imagine · FRKarolinska Institutet · SEUniversitat Autònoma de Barcelona · ESNational and Kapodistrian University of Athens · GRUniversidad de Las Palmas de Gran Canaria · ESUniversité Claude Bernard Lyon 1 · FRUniversity of Hassan II Casablanca · MAInnsbruck Medical University · ATAarhus University · DKAzienda USL di Bologna · ITGhent University Hospital · BEHôpital Necker-Enfants Malades · FRHoward Hughes Medical Institute · USInstitut d'Investigació Biomédica de Bellvitge · ESKU Leuven · BEMcGill University Health Centre · CATokyo Medical and Dental University · JP

Funding

Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6M
Transforming Translational Science and Education to Benefit Human HealthUL1TR000043 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY · 2012 to 2015
$26.8M
Host factors contributing to susceptibility to COVID-19 diseaseZIAAI001265 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SU, HELEN CHUN-HUI · 2020 to 2025
$9.5M
Monogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19R01AI088364 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Jean-Laurent Casanova, Shen-Ying Zhang · 2010 to 2026
$8.7M
Inborn errors of immunity in patients with life-threatening COVID-19R01AI163029 · NIAID · ROCKEFELLER UNIVERSITY · PI CASANOVA, JEAN-LAURENT, ZHANG, QIAN · 2021 to 2025
$3.7M
Single gene inborn errors of immunity underlying SARS-CoV-2-related multisystem inflammatory syndrome in children: a new approach to tackle a seemingly old puzzleR21AI160576 · NIAID · ROCKEFELLER UNIVERSITY · PI ZHANG, SHEN-YING · 2022 to 2023
$466k
European Research Council HORIZON-HLTL-2021-ID: 101057100 "Undine"Howard Hughes Medical InstituteMedical Research Council MR/S032304/1NCATS NIH HHS UL1 TR000043NCATS NIH HHS UL1 TR001866NCATS NIH HHS UL1TR001866NIAID NIH HHS R01 AI088364NIAID NIH HHS R01 AI163029NIAID NIH HHS R21 AI160576NIH HHS R01AI088364
6 · The paper itself

Abstract

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-ω and/or IFN-α2.

Indexed as

COVID-19Interferon Type IAutoantibodiesChildHumansInterferon-alphaAutoantibodiesInterferon-alphaInterferon Type I

Identifiers

PMID38175961
PMCPMC10771097
OpenAlexW4390576813

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.