Evidence map›Paper›PMID 38175916›Full record

ArticleACS chemical neuroscience2024

New Imidazodiazepine Analogue, 5-(8-Bromo-6-(pyridin-2-yl)-4

Dishary Sharmin, Branka Divović, Xingjie Ping, Rok Cerne, Jodi L Smith, Sepideh Rezvanian, Prithu Mondal, Michelle Jean Meyer, Molly E Kiley, Leggy A Arnold and 11 more

Open access · greenAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 4 countries.

Dishary SharminDepartment of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States.ORCID 0000-0003-0417-4262
Branka DivovićDepartment of Pharmacology, Faculty of Pharmacy, University of Belgrade, Belgrade 11221, Serbia.
Xingjie PingDepartment of Anatomy and Cell Biology, Indiana University/Purdue University, Indianapolis, Indiana 46202, United States.
Rok CerneDepartment of Anatomy and Cell Biology, Indiana University/Purdue University, Indianapolis, Indiana 46202, United States.
Jodi L SmithLaboratory of Antiepileptic Drug Discovery, St. Vincent's Hospital, Indianapolis, Indiana 46260, United States.
Sepideh RezvanianDepartment of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States.
Prithu MondalDepartment of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States.
Michelle Jean MeyerDepartment of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States.
Molly E KileyDepartment of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States.
Leggy A ArnoldDepartment of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States.ORCID 0000-0003-1411-1572
Md Yeunus MianDepartment of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States.ORCID 0000-0002-7520-1750
Kamal P PandeyDepartment of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States.ORCID 0000-0002-0723-2264
Xiaoming JinDepartment of Anatomy and Cell Biology, Indiana University/Purdue University, Indianapolis, Indiana 46202, United States.
Jelena R MitrovićDepartment of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Belgrade 11221, Serbia.
Djordje DjorovićInstitute of Anatomy, School of Medicine, University of Belgrade, Belgrade 11221, Serbia.
Arnold LippaRespireRx Pharmaceuticals Inc, Glen Rock, New Jersey 07452, United States.
James M CookDepartment of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States.ORCID 0000-0001-5512-3022
Lalit K GolaniDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Petra ScholzeDepartment of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Vienna 1090, Austria.ORCID 0000-0003-4984-6034
Miroslav M SavićDepartment of Pharmacology, Faculty of Pharmacy, University of Belgrade, Belgrade 11221, Serbia.ORCID 0000-0002-6934-9193
Jeffrey M WitkinDepartment of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States.
University of Wisconsin–Milwaukee · USUniversity of Belgrade · RSSt. Vincent's Birmingham · USIndiana University – Purdue University Indianapolis · USMedical University of Vienna · ATNortheastern University · US

Funding

Tolerance and Physical Dependence after Chronic Benzodiazepine TreatmentR01DA043204 · NIDA · UNIVERSITY OF MISSISSIPPI MED CTR · PI JAMES K ROWLETT · 2017 to 2026
$4.3M
Benzodiazepine Choice and Polydrug UseR01DA054177 · NIDA · UNIVERSITY OF MISSISSIPPI MED CTR · PI Sally L Huskinson · 2022 to 2026
$2.5M
GABA-A receptor subtype mechanisms and the abuse-related effects of alcoholR01AA029023 · NIAAA · UNIVERSITY OF MISSISSIPPI MED CTR · PI PLATT, DONNA M · 2020 to 2024
$2.4M
Synthesis of Alpha2/Alpha3 GABA Agonists to Treat Neuropathic PainR01NS076517 · NINDS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2012 to 2015
$1.3M
NIAAA NIH HHS R01 AA029023NIDA NIH HHS R01 DA043204NIDA NIH HHS R01 DA054177NINDS NIH HHS R01 NS076517
6 · The paper itself

Abstract

KRM-II-81 (1) is an imidazodiazepine GABA

Indexed as

Epilepsy, Temporal LobeAnimalsAnticonvulsantsBrainHumansHypnotics and SedativesMiceMolecular Docking SimulationNeural Networks, ComputerOxazolesRatsReceptors, GABA-ASeizuresAnticonvulsantsHypnotics and SedativesOxazolesReceptors, GABA-AanticonvulsantDS-II-73human epilepsyimidazodiazepinepharmacokinetics

Identifiers

PMID38175916
PMCPMC12931607
OpenAlexW4390577859

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.