ArticleScience (New York, N.Y.)2024
Cobalt-catalyzed synthesis of amides from alkenes and amines promoted by light.
Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The trial behind it
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Who cites it
18 citing papers in PubMed.
- Cobalt-Catalyzed Cyclohydrocarbonylations: Syntheses of Saturated Heterocycles Promoted by Light.Journal of the American Chemical Society · 2026Article
- Mechanistic Investigation of [CoJournal of the American Chemical Society · 2026Article
- Cobalt-Catalyzed Highly Regioselective Alkoxycarbonylation of Olefins Driven by Light.Journal of the American Chemical Society · 2026Article
- Cobalt-Catalyzed Syntheses of Acrylamides and Succindiamides from Alkynes and Amines Promoted by Light.Journal of the American Chemical Society · 2026Article
- Cobalt-Catalyzed Carbonylative Conversion of Unactivated Alkyl Chlorides.Journal of the American Chemical Society · 2026Article
- Ambient Hydrocarbonylation of Olefins Enabled by Visible-Light.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Divergent Access to α,β-Unsaturated Thiolated and Selenolated Lactams via a Unified Palladium-Catalyzed Carbonylative Transformation.Organic letters · 2026Article
- Activation of Cyanate Anions by Phosphine Radical Cations Enables Formal Hydrocarbamoylation of Alkenes.Angewandte Chemie (International ed. in English) · 2026Article
- Recent Advances in Single-Electron-Transfer-Mediated Carbonylation.Chemical reviews · 2026Review
- Nickel-catalyzed highly diastereo- and enantioselective hydroaminocarbonylation and hydrocarboxylation of cyclopropenes.Nature communications · 2025Article
- Shedding Light on Photochemical Activation and Catalytic Mechanism of Cobalt-Catalyzed Alkene Hydroaminocarbonylation.ACS catalysis · 2025Article
- Pincer-cobalt boosts divergent alkene carbonylation under tandem electro-thermo-catalysis.Nature communications · 2025Article
- Palladium-Catalyzed Carbonylative Fluoroalkylation of 1,3-Enynes to Access Allenyl Primary Amides.Organic letters · 2025Article
- Amino-substituted triazatriangulenium photosensitizers for CONature communications · 2025Article
- Copper-catalyzed photoinduced carbonylation of C1-C3 gaseous alkanes.Nature communications · 2025Article
- Cobalt-Catalyzed Syntheses of Esters and Carboxylic Acids from Alkenes Promoted by Light.Journal of the American Chemical Society · 2025Article
- Oxygen Vacancies in β-MoOResearch (Washington, D.C.) · 2025Article
- Enantioconvergent synthesis of axially chiral amides enabled by Pd-catalyzed dynamic kinetic asymmetric aminocarbonylation.Nature communications · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Catalytic methods to couple alkene and amine feedstocks are valuable in synthetic chemistry. The direct carbonylative coupling of alkenes and amines holds promise as a perfectly atom-economical approach to amide synthesis, but general methods remain underdeveloped. Herein, we report an alkene hydroaminocarbonylation catalyzed by unmodified, inexpensive cobalt carbonyl under mild conditions and low pressure promoted by light. Silane addition after the reaction enables sequential cobalt-catalyzed amide reduction, constituting a formal alkene hydroaminomethylation. These methods exhibit exceptional scope across both alkene and amine components with high chemo- and regioselectivity and proceed efficiently even in the absence of solvent. The formation of a hydridocobalt through photodissociation of a carbonyl ligand is proposed to enable catalytic activity under mild conditions, which addresses a long-standing challenge in catalysis.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.