Evidence map›Paper›PMID 38175522›Full record

ArticleJournal of nephrology2024

Twenty years in the making: tolerance in a living-related kidney transplant recipient.

Manal Alotaibi, Ziad Alahmadi, Niraj Desai, Daniel C Brennan, Sam Kant

Abstract readCase Reports
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In one paragraph

Article in Journal of nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Manal AlotaibiComprehensive Transplant Center and Division of Nephrology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA. Meotaibi@hotmail.com.ORCID 0000-0002-5349-9939
Ziad AlahmadiDepartment of Medicine, University of Maryland Medical Center, Baltimore, MD, USA.
Niraj DesaiDepartment of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Daniel C BrennanComprehensive Transplant Center and Division of Nephrology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Sam KantComprehensive Transplant Center and Division of Nephrology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kidney transplant recipients require lifelong immunosuppression to prevent graft rejection. However, immunosuppression is associated with adverse effects. A minority of kidney transplant recipients can be weaned off immunosuppression and maintain their graft function, a situation referred to as "functional or operational tolerance". We describe a case of a 70-year-old man who received a haploidentical hematopoietic cell transplant for lymphoma 22 years before receiving a kidney transplant from the same donor and was weaned off all immunosuppression by four months post-transplant. Tolerance was present, and there has been no graft rejection or graft vs. host disease. This case demonstrates successful long-term hematopoietic chimerism and functional tolerance after receiving a kidney transplant from the same donor.

Indexed as

Hematopoietic Stem Cell TransplantationKidney TransplantationLiving DonorsAgedHumansImmunosuppressive AgentsLymphomaMaleTime FactorsTransplantation ChimeraTransplantation ToleranceTreatment OutcomeImmunosuppressive AgentsHLALiving donor kidney transplantTolerance

Identifiers

PMID38175522

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.