Evidence map›Paper›PMID 38175499›Full record

ArticleJournal of physiology and biochemistry2024

Lactate coordinated with exercise promoted the browning of inguinal white adipose tissue.

Xuefei Chen, Yanjun Li, Jingbo Zhang, Wenhua Huang, Jie Su, Jing Zhang

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Article in Journal of physiology and biochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xuefei Chen *School of Physical education (Main campus), Zhengzhou University, Zhengzhou, China.
Yanjun Li *College of P.E. and Sports, Beijing Normal University, Beijing, China.
Jingbo ZhangCollege of P.E. and Sports, Beijing Normal University, Beijing, China.
Wenhua HuangCollege of P.E. and Sports, Beijing Normal University, Beijing, China.
Jie SuCollege of P.E. and Sports, Beijing Normal University, Beijing, China.
Jing ZhangCollege of P.E. and Sports, Beijing Normal University, Beijing, China. zhangjing@bnu.edu.cn.ORCID http://orcid.org/0000-0003-1766-7576

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lactate, an important exercise metabolite, induces white adipose tissue browning by upregulated uncoupling protein 1 (UCP1) expression. However, the function of lactate during browning of inguinal white adipose tissue (iWAT) caused by exercise is unclear. Here, we considered lactate as an exercise supplement and investigated the effects of chronic pre-exercise lactate administration on energy metabolism and adipose tissue browning. C57B/L6 male mice (5 weeks of age) were divided into six groups. We evaluated the changes in blood lactate levels in each group of mice after the intervention. Energy expenditure was measured after the intervention immediately by indirect calorimetry. The marker protein levels and gene expressions were determined by western-blot and quantitative real-time PCR. HIIT significantly decreased adipose tissue weight while increased energy expenditure and the expression of UCP1 in iWAT; however, these regulations were inhibited in the DCA+HIIT group. Compared with the MICT and LAC groups, long-term lactate injection before MICT led to lower WAT weight to body weight ratios and higher energy expenditure in mice. Furthermore, the marker genes of browning in iWAT, such as Ucp1 and Pparγ, were significantly increased in the LAC+MICT group than in the other groups, and the expression of monocarboxylate transporter-1 (Mct1) mRNA was also significantly increased. Lactate was involved in exercise-mediated browning of iWAT, and its mechanism might be the increased of lactate transport through MCT1 or PPARγ upregulation induced by exercise. These findings suggest exogenous lactate may be a new exercise supplement to regulate metabolism.

Indexed as

Adipose Tissue, BrownAdipose Tissue, WhiteEnergy MetabolismLactic AcidMice, Inbred C57BLPhysical Conditioning, AnimalSymportersUncoupling Protein 1AnimalsMaleMiceMonocarboxylate Transport Protein 1Monocarboxylic Acid TransportersPPAR gammaLactic AcidMonocarboxylate Transport Protein 1Monocarboxylic Acid TransportersPPAR gammaSymportersUcp1 protein, mouseUncoupling Protein 1ExerciseLactate supplementUCP1White adipose tissue browning

Identifiers

PMID38175499

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.