Evidence map›Paper›PMID 38175434›Full record

ArticleJournal of hematopathology2023

Oral follicular lymphoma: a clinicopathologic and molecular study.

Lucas Lacerda de Souza, Cinthia Veronica Bardález López de Cáceres, Maria Sissa Pereira Sant'Ana, Paulo Victor Mendes Penafort, Bruno Augusto Benevenuto de Andrade, Hélder Antônio Rebelo Pontes, Wagner Henriques de Castro, Ricardo Alves Mesquita, José Cândido Caldeira Xavier-Júnior, Alan Roger Santos-Silva and 10 more

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Journal of hematopathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 2 countries.

Lucas Lacerda de SouzaOral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.ORCID 0000-0002-9481-7796
Cinthia Veronica Bardález López de CáceresDepartment of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Maria Sissa Pereira Sant'AnaDepartment of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Paulo Victor Mendes PenafortOral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Bruno Augusto Benevenuto de AndradeDepartment of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Hélder Antônio Rebelo PontesService of Oral Pathology, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil.
Wagner Henriques de CastroDepartment of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Ricardo Alves MesquitaDepartment of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
José Cândido Caldeira Xavier-JúniorPathology Institute of Araçatuba and School of Medicine, Centro Universitário Católico Unisalesiano Auxilium, Araçatuba, Brazil.
Alan Roger Santos-SilvaOral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Márcio Ajudarte LopesOral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Ciro Dantas SoaresGetúlio Sales Diagnósticos, Natal, Brasil.
Liam RobinsonDepartment of Oral and Maxillofacial Pathology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Willie F P van HeerdenDepartment of Oral and Maxillofacial Pathology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Rommel Mario Rodríguez BurbanoLaboratory of Molecular Biology, Ophir Loyola Hospital, Belém, Brazil.
Guilherme Rossi Assis-MendonçaMultipat Anatomic Pathology and Molecular Pathology Laboratory, Campinas, Brazil.
José VassalloMultipat Anatomic Pathology and Molecular Pathology Laboratory, Campinas, Brazil.
Silvia Ferreira de SousaDepartment of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Pablo Agustin VargasOral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Felipe Paiva FonsecaDepartment of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. felipepfonseca@hotmail.com.
Universidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal de Minas Gerais · BRUniversity of Pretoria · ZACentro Universitário Católico Salesiano Auxilium · BRUniversidade Federal do Pará · BRUniversidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Follicular lymphoma is a hematolymphoid neoplasm that originates from germinal center B cells. It is made up of a combination of small cleaved centrocytes and a varying quantity of larger non-cleaved centroblasts to describe the clinical, microscopic, immunohistochemical, and molecular features of oral follicular lymphomas. Follicular lymphomas affecting the oral cavity were retrieved from pathology files. Immunohistochemistry was performed to confirm the diagnosis, and fluorescence in situ hybridization (FISH) was employed to detect rearrangements in BCL2, BCL6, and MYC genes. Clinical and follow-up data were obtained from the patient's medical and pathology files. Twenty cases were obtained. There was an equal sex distribution (10 males: 10 females) and a mean age of 60.9 years (range: 10-83 years-old). Lesions presented as asymptomatic swellings, usually in the palate (10 cases) and the buccal mucosa (7 cases). Five patients presented with concomitant nodal involvement. Microscopic evaluation depicted the follicular growth pattern with diffuse areas in six cases. Grades 1 and 2 follicular lymphomas represented 12 cases, while grade 3A neoplasms accounted for other 8 cases. Two cases showed rearrangements in MYC, BCL2, and BCL6 genes, while single BCL2 translocation was found in eight cases. Two cases had no translocation. Three patients deceased and the 2-year overall survival achieved 88%. Follicular lymphoma affecting the oral cavity is uncommon, usually affects the palate as a non-ulcerated swelling and the presence of a systemic disease most always be ruled out.

Indexed as

Lymphoma, FollicularAdolescentAdultAgedAged, 80 and overB-LymphocytesChildFemaleGerminal CenterHumansIn Situ Hybridization, FluorescenceMaleMiddle AgedProto-Oncogene Proteins c-bcl-2Translocation, GeneticYoung AdultProto-Oncogene Proteins c-bcl-2Buccal mucosaFollicular lymphomaLymphomaOral cavityPalate

Identifiers

PMID38175434
OpenAlexW4388233042

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.