ReviewDiscover mental health2024
Distinguishing features of depression in dementia from primary psychiatric disease.
Review in Discover mental health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.Nutrients · 2025Trial
- Possible and Probable Dementia and Depressive/Anxiety Symptoms in U.S. Older Adults: One-Year Follow-Up.Journal of aging and health · 2026Article
- Long-Term Cognitive and Functional Outcomes of Anesthesia and Surgery in Patients with Dementia.Healthcare (Basel, Switzerland) · 2026Review
- Article
- Methodological adaptations for applying the Harmonised Cognitive Assessment Protocol diagnostic algorithm in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA-HCAP).BMC research notes · 2026Article
- Affective neuropsychiatric symptom metrics in the National Alzheimer's Coordinating Center dataset.Journal of Alzheimer's disease : JAD · 2026Article
- "We have a behaviour support plan, let's have a mental health support plan": Perspectives of staff, residents and family carers on understanding, responding to and promoting the mental health of residents within long-term care.Dementia (London, England) · 2026Article
- Clinical Associations and Possible Risk Factors for Affective Neuropsychiatric Symptoms in Older Adults With and Without Cognitive Impairment.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Cognitive Impairment, Dementia and Depression in Older Adults.Journal of clinical medicine · 2026Review
- Somatic Symptom Disorder as a Prodrome of Alzheimer Disease and Successful Treatment of Pain and Agitation With Electroconvulsive Therapy: A Case Report.The journal of ECT · 2026Article
- Risk of depression after new-onset dementia or cognitive impairment: the Health and Retirement Study.Innovation in aging · 2026Article
- Affective Neuropsychiatric Symptom Metrics in the National Alzheimer's Coordinating Center Dataset.medRxiv : the preprint server for health sciences · 2025Article
- Uncovering the genetic underpinnings for different psychiatric disorder combinations.Psychological medicine · 2025Article
- Comorbidities predict institutionalization and mortality in biomarker-confirmed alzheimer's disease.Alzheimer's research & therapy · 2025Article
- Neuropsychiatric symptoms in mild cognitive impairment and early Alzheimer's disease: Clinical pattern and diagnostic implications.AIMS neuroscience · 2025Review
- Exploring the Complex Relationship Between Antidepressants, Depression and Neurocognitive Disorders.Biomedicines · 2024Review
- Impact of the gut microbiota-Th17 cell axis on inflammatory depression.Frontiers in psychiatry · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Depression is a common and devastating neuropsychiatric symptom in the elderly and in patients with dementia. In particular, nearly 80% of patients with Alzheimer's Disease dementia experience depression during disease development and progression. However, it is unknown whether the depression in patients with dementia shares the same molecular mechanisms as depression presenting as primary psychiatric disease or occurs and persists through alternative mechanisms. In this review, we discuss how the clinical presentation and treatment differ between depression in dementia and as a primary psychiatric disease, with a focus on major depressive disorder. Then, we hypothesize several molecular mechanisms that may be unique to depression in dementia such as neuropathological changes, inflammation, and vascular events. Finally, we discuss existing issues and future directions for investigation and treatment of depression in dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.