Evidence map›Paper›PMID 38175404›Full record

ArticleJournal of hematopathology2023

"Quadruple-hit" primary testicular diffuse large B-cell lymphoma with MYD88 L265P mutation, IGH::MYC, and IRF4- and BCL6-rearrangements.

Frido K Bruehl, Rhett P Ketterling, Lisa M Rimsza, Edward F Santos, Ellen D McPhail

Open access · bronzeAbstract readCase Reports
PubMed Publisher
In one paragraph

Article in Journal of hematopathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Frido K BruehlDepartment of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.ORCID 0000-0001-6409-0824
Rhett P KetterlingDepartment of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.ORCID 0000-0001-6479-7897
Lisa M RimszaDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ, USA.ORCID 0000-0003-1268-2750
Edward F SantosDepartment of Pathology, OSF Saint Anthony Medical Center, Rockford, IL, USA.
Ellen D McPhailDepartment of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. McPhail.Ellen@mayo.edu.ORCID 0000-0001-6918-3376
Mayo Clinic · USMayo Clinic in Arizona · USOSF Saint Anthony Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Classification of DLBCL relies on clinical, immunohistochemical, and genetic information. We report a case of primary testicular diffuse large B-cell lymphoma (PT-DLBCL) with a hitherto unreported constellation of pathologic findings to illustrate the challenges of DLBCL classification. A standard hematopathology workup was followed by gene expression profiling (GEP) to determine the DLBCL cell of origin (COO). A 75-year-old man presented with a unilateral testicular mass that had developed over the course of 1 month. Pathologic examination demonstrated involvement by DLBCL. Clinical staging revealed no systemic disease. Genetic testing showed an MYD88 mutation, as well as IGH::MYC and IRF4- and BCL6-rearrangements. Gene expression profiling demonstrated an activated B-cell expression profile. This case highlights the genetic complexity of DLBCL arising in the testis and questions the clinical significance of the identified genetic abnormalities.

Indexed as

Lymphoma, Large B-Cell, DiffuseTesticular NeoplasmsAgedGenetic TestingHumansMaleMutationMyeloid Differentiation Factor 88Proto-Oncogene Proteins c-bcl-6BCL6 protein, humanMyeloid Differentiation Factor 88Proto-Oncogene Proteins c-bcl-6IGH::MYCIRF4-rearrangementMYD88 mutationPrimary testicular diffuse large B-cell lymphoma (PT-DLBCL)

Identifiers

PMID38175404
OpenAlexW4385581370

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.