ArticleeLife2024
Cell type-specific connectome predicts distributed working memory activity in the mouse brain.
Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 15 citations in OpenAlex.
- Noisy models of the ventral stream reveal the impact of recurrence and learned representations on information processing timescales.PLoS computational biology · 2026Article
- Resting fMRI functional connectivity reflects fluctuations in inhibitory interneuron activity.bioRxiv : the preprint server for biology · 2026Article
- Competitive interactions shape mammalian brain network dynamics and computation.Nature neuroscience · 2026Article
- Biophysical mechanisms of default mode network function and dysfunction.bioRxiv : the preprint server for biology · 2026Article
- Attractor dynamics of a whole-cortex network model predicts emergence and structure of fMRI co-activation patterns in the mouse brain.PLoS computational biology · 2026Article
- Article
- Simultaneously determining regional heterogeneity and connection directionality from neural activity and symmetric connection.PLoS computational biology · 2025Article
- Bifurcation in space: Emergence of functional modularity in the neocortex.bioRxiv : the preprint server for biology · 2025Article
- Cognitive processes are disentangled at cortex-wide scales.bioRxiv : the preprint server for biology · 2025Article
- Integrated Classification of Cortical Cells and Quantitative Projectomic Mapping Unveil Organizational Principles of Brain-Wide Connectomes at Single Cell Level.bioRxiv : the preprint server for biology · 2025Article
- Network Mechanisms Underlying the Regional Diversity of Variance and Time Scales of the Brain's Spontaneous Activity Fluctuations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cognitive network interactions through communication subspaces in large-scale models of the neocortex.bioRxiv : the preprint server for biology · 2024Article
- Signatures of hierarchical temporal processing in the mouse visual system.PLoS computational biology · 2024Article
- The meso-connectomes of mouse, marmoset, and macaque: network organization and the emergence of higher cognition.Cerebral cortex (New York, N.Y. : 1991) · 2024Review
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 4 countries.
Funding
Abstract
Recent advances in connectomics and neurophysiology make it possible to probe whole-brain mechanisms of cognition and behavior. We developed a large-scale model of the multiregional mouse brain for a cardinal cognitive function called working memory, the brain's ability to internally hold and process information without sensory input. The model is built on mesoscopic connectome data for interareal cortical connections and endowed with a macroscopic gradient of measured parvalbumin-expressing interneuron density. We found that working memory coding is distributed yet exhibits modularity; the spatial pattern of mnemonic representation is determined by long-range cell type-specific targeting and density of cell classes. Cell type-specific graph measures predict the activity patterns and a core subnetwork for memory maintenance. The model shows numerous attractor states, which are self-sustained internal states (each engaging a distinct subset of areas). This work provides a framework to interpret large-scale recordings of brain activity during cognition, while highlighting the need for cell type-specific connectomics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.