Evidence map›Paper›PMID 38174377›Full record

ReviewAmerican journal of physiology. Renal physiology2024

Recent advances in understanding the kidney circadian clock mechanism.

Alexandria Juffre, Michelle L Gumz

Open access · greenAbstract readReview
In one paragraph

Review in American journal of physiology. Renal physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alexandria JuffreDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.ORCID 0009-0009-8175-0738
Michelle L GumzDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.ORCID 0000-0002-1342-0878
University of Florida · US

Funding

Coordinating Unit for the Innovative Science Accelerator ProgramU24DK128851 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2021 to 2025
$6.7M
Per1 and the kidney clock in hypertensionR01DK109570 · NIDDK · UNIVERSITY OF FLORIDA · PI GUMZ, MICHELLE L · 2017 to 2021
$1.5M
Modulation of the renal aldosterone endothelin feedback system by the clock protein PER1R56DK128271 · NIDDK · UNIVERSITY OF FLORIDA · PI GUMZ, MICHELLE L, WINGO, CHARLES S · 2021 to 2021
$100k
NIDDK NIH HHS R01 DK109570NIDDK NIH HHS R56 DK128271NIDDK NIH HHS U24 DK128851
6 · The paper itself

Abstract

Circadian rhythms are endogenous biological oscillations that regulate various physiological processes in organisms, including kidney function. The kidney plays a vital role in maintaining homeostasis by regulating water and electrolyte balance, blood pressure, and excretion of metabolic waste products, all of which display circadian rhythmicity. For this reason, studying the circadian regulation of the kidney is important, and the time of day is a biological and experimental variable that must be considered. Over the past decade, considerable progress has been made in understanding the molecular mechanisms underlying circadian regulation within the kidney. In this review, the current knowledge regarding circadian rhythms in the kidney is explored, focusing on the molecular clock machinery, circadian control of renal functions, and the impact of disrupted circadian rhythms on kidney health. In addition, parameters that should be considered and future directions are outlined in this review.

Indexed as

Circadian ClocksCircadian RhythmHomeostasisKidneyWater-Electrolyte Balanceblood pressurecircadian rhythmendothelinrenal functionsex differences

Identifiers

PMID38174377
PMCPMC11207534
OpenAlexW4390583388

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.