Evidence map›Paper›PMID 38174348›Full record

ArticleEuropean heart journal open2024

Cerebral blood flow and neurocognition in patients undergoing transcatheter aortic valve replacement for severe aortic stenosis.

Ronald M Lazar, Terina Myers, Toby I Gropen, Massoud A Leesar, James Davies, Adam Gerstenecker, Amani Norling, Marykay A Pavol, Randolph S Marshall, Susheel Kodali

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ronald M LazarDepartment of Neurology, University of Alabama at Birmingham, 1720 7th Avenue South, SC650K, Birmingham, AL 35294, USA.ORCID https://orcid.org/0000-0002-7388-042X
Terina MyersDepartment of Neurology, University of Alabama at Birmingham, 1720 7th Avenue South, SC650K, Birmingham, AL 35294, USA.ORCID https://orcid.org/0000-0002-2921-2301
Toby I GropenDepartment of Neurology, University of Alabama at Birmingham, 1720 7th Avenue South, SC650K, Birmingham, AL 35294, USA.ORCID https://orcid.org/0000-0003-0043-6755
Massoud A LeesarDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID https://orcid.org/0000-0002-8594-2982
James DaviesDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Adam GersteneckerDepartment of Neurology, University of Alabama at Birmingham, 1720 7th Avenue South, SC650K, Birmingham, AL 35294, USA.ORCID https://orcid.org/0000-0003-2696-5380
Amani NorlingDepartment of Neurology, University of Alabama at Birmingham, 1720 7th Avenue South, SC650K, Birmingham, AL 35294, USA.ORCID https://orcid.org/0000-0003-1638-5913
Marykay A PavolDepartment of Neurology, Columbia University Irving Medical Center, 710 W168th Street, NewYork, NY 10032, USA.ORCID https://orcid.org/0000-0002-0270-7443
Randolph S MarshallDepartment of Neurology, Columbia University Irving Medical Center, 710 W168th Street, NewYork, NY 10032, USA.ORCID https://orcid.org/0000-0003-3037-0283
Susheel KodaliDepartment of Medicine, Columbia University Irving Medical Center, NewYork, NY, USA.ORCID https://orcid.org/0000-0003-0517-2074
University of Alabama at Birmingham · USColumbia University Irving Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Aortic valve stenosis (AS) results in higher systolic pressure to overcome resistance from the stenotic valve, leading to heart failure and decline in cardiac output. There has been no assessment of cerebral blood flow (CBF) association with neurocognition in AS or the effects of valve replacement. The goal was to determine if AS is associated with altered cerebral haemodynamics and impaired neurocognition, and whether transcatheter aortic valve replacement (TAVR) improves haemodynamics and cognition. Methods and results: In 42 patients with planned TAVR, transcranial Doppler (TCD) assessed bilateral middle cerebral artery (MCA) mean flow velocities (MFVs); abnormality was <34.45 cm/s. The neurocognitive battery assessed memory, language, attention, visual-spatial skills, and executive function, yielding a composite Conclusion: Among patients with severe AS, there was little impairment of MFV on TCD and no correlation with cognition. Transcatheter aortic valve replacement did not affect MFV or cognition. Assumptions about diminished CBF and improvement after TAVR were not supported.

Indexed as

Aortic valve stenosisCerebral blood flowNeurocognitionTAVR

Identifiers

PMID38174348
PMCPMC10763524
OpenAlexW4389426693

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.