Evidence map›Paper›PMID 38174147›Full record

ArticleWorld journal of transplantation2023

Dosing strategies for

Adam Diamond, Sunil Karhadkar, Kenneth Chavin, Serban Constantinescu, Kwan N Lau, Oscar Perez-Leal, Kerry Mohrien, Nicole Sifontis, Antonio Di Carlo

Abstract read
In one paragraph

Article in World journal of transplantation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Adam DiamondDepartment of Pharmacy, Temple University Hospital, Philadelphia, PA 19140, United States.
Sunil KarhadkarDepartment of Surgery, Temple University Hospital, Philadelphia, PA 19140, United States. sunilk@temple.edu.
Kenneth ChavinDepartment of Surgery, Temple University Hospital, Philadelphia, PA 19140, United States.
Serban ConstantinescuDepartment of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, United States.
Kwan N LauDepartment of Surgery, Temple University Hospital, Philadelphia, PA 19140, United States.
Oscar Perez-LealDepartment of Pharmaceutical Sciences, Jayne Haines Center for Phar macogenomics and Drug Safety, Temple University School of Pharmacy, Philadelphia, PA 19140, United States.
Kerry MohrienDepartment of Pharmacy, Temple University Hospital, Philadelphia, PA 19140, United States.
Nicole SifontisDepartment of Pharmacy Practice, Temple University School of Pharmacy, Philadelphia, PA 19140, United States.
Antonio Di CarloDepartment of Surgery, Temple University Hospital, Philadelphia, PA 19140, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTacrolimus extended-release tablets have been Food and Drug Administration-approved for use in the

aimTo obtain target trough concentrations of extended-release tacrolimus in

methodsSingle-arm, prospective, single-center, open-label, observational study (ClinicalTrials.gov: NCT037 13645). Life cycle pharma tacrolimus (LCPT) orally once daily at a starting dose of 0.13 mg/kg/day based on actual body weight. If weight is more than 120% of ideal body weight, an adjusted body weight was used. LCPT dose was adjusted to maintain tacrolimus trough concentrations of 8-10 ng/mL. Pharmacogenetic analysis of

resultsMean time to therapeutic tacrolimus trough concentration was longer in

conclusionExpression of

Indexed as

DosingGenotypeImmunosuppressionKidney transplantTacrolimusTherapeutic drug monitoring

Identifiers

PMID38174147
PMCPMC10758687

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.