Evidence map›Paper›PMID 38174052›Full record

ArticleCerebral circulation - cognition and behavior2024

Small vessel disease burden and functional brain connectivity in mild cognitive impairment.

Sofia Marcolini, Jaime D Mondragón, Esther E Bron, Geert J Biessels, Jurgen A H R Claassen, Janne M Papma, Huub Middelkoop, Rudi A J O Dierckx, Ronald J H Borra, Inez H G B Ramakers and 3 more

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Article in Cerebral circulation - cognition and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Sofia MarcoliniDepartment of Neurology, University Medical Center Groningen, University of Groningen, Groningen 9713 GZ, the Netherlands.
Jaime D MondragónDepartment of Neurology, University Medical Center Groningen, University of Groningen, Groningen 9713 GZ, the Netherlands.
Esther E BronDepartment of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam 3015 GD, the Netherlands.
Geert J BiesselsDepartment of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht 3584 CX, the Netherlands.
Jurgen A H R ClaassenDepartment of Geriatrics, Radboud University Medical Center and Donders Institute, Nijmegen 6525 GD, the Netherlands.
Janne M PapmaDepartment of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam 3015 GD, the Netherlands.
Huub MiddelkoopInstitute of Psychology, Health, Medical and Neuropsychology Unit, Leiden University, Leiden 2316 XC, the Netherlands.
Rudi A J O DierckxDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen 9713 GZ, the Netherlands.
Ronald J H BorraDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen 9713 GZ, the Netherlands.
Inez H G B RamakersAlzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht 6229 ER, the Netherlands.
Wiesje M van der FlierDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam 1081 HZ, the Netherlands.
Natasha M MauritsDepartment of Neurology, University Medical Center Groningen, University of Groningen, Groningen 9713 GZ, the Netherlands.
Peter P De DeynDepartment of Neurology, University Medical Center Groningen, University of Groningen, Groningen 9713 GZ, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The role of small vessel disease in the development of dementia is not yet completely understood. Functional brain connectivity has been shown to differ between individuals with and without cerebral small vessel disease. However, a comprehensive measure of small vessel disease quantifying the overall damage on the brain is not consistently used and studies using such measure in mild cognitive impairment individuals are missing. Method: Functional brain connectivity differences were analyzed between mild cognitive impairment individuals with absent or low ( Results: Functional connectivity between areas of the cerebellum and between the cerebellum and the thalamus and caudate nucleus was higher in the absent or low small vessel disease group compared to the high small vessel disease group. Conclusion: These findings might suggest that functional connectivity of mild cognitive impairment individuals with low or absent small vessel disease burden is more intact than in mild cognitive impairment individuals with high small vessel disease. These brain areas are mainly responsible for motor, attentional and executive functions, domains which in previous studies were found to be mostly associated with small vessel disease markers. Our results support findings on the involvement of the cerebellum in cognitive functioning.

Indexed as

Alzheimer's diseaseDisease mechanismsMicrovesselsNeurovascular couplingRisk factors

Identifiers

PMID38174052
PMCPMC10758699

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.