Evidence map›Paper›PMID 38173659›Full record

ReviewCancer diagnosis & prognosis

PTEN Deregulation Mechanisms in Salivary Gland Carcinomas.

Vasileios Papanikolaou, Aristeidis Chrysovergis, Maria Adamopoulou, Despoina Spyropoulou, Dimitrios Roukas, George Papanastasiou, Sofianiki Mastronikoli, Sotirios Papouliakos, Loukas Manaios, Evangelos Tsiambas and 6 more

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer diagnosis & prognosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 3 countries.

Vasileios PapanikolaouFirst Department of Otolaryngology, Hippocration Hospital, University of Athens, Athens, Greece.
Aristeidis ChrysovergisFirst Department of Otolaryngology, Hippocration Hospital, University of Athens, Athens, Greece.
Maria Adamopoulou *Biomedical Sciences Program, Department of Science and Mathematics, Deree American College, Athens, Greece.
Despoina Spyropoulou *Department of Radiation Oncology, Medical School, University of Patras, Patras, Greece.
Dimitrios Roukas *Department of Psychiatry, 417 Veterans Army Hospital (NIMTS), Athens, Greece.
George Papanastasiou *Department of Maxillofacial Surgery, Medical School, University of Ioannina, Ioannina, Greece.
Sofianiki MastronikoliBrighton and Sussex Medical School, Brighton, U.K.
Sotirios PapouliakosDepartment of Otolaryngology, Gennimatas GNA Hospital, Athens, Greece.
Loukas ManaiosDepartment of Surgery, BIOCLINIC, Athens, Greece.
Evangelos TsiambasDepartment of Cytology, 417 Veterans Army Hospital (NIMTS), Athens, Greece.
Pavlos PantosFirst Department of Otolaryngology, Hippocration Hospital, University of Athens, Athens, Greece.
Vasileios RagosDepartment of Maxillofacial Surgery, Medical School, University of Ioannina, Ioannina, Greece.
Panagotis FotiadesDepartment of Surgery, 424 General Army Hospital, Thessaloniki, Greece.
Dimitrios PeschosDepartment of Physiology, Medical School, University of Ioannina, Ioannina, Greece.
Nicholas MastronikolisDepartment of Otolaryngology, Medical School, University of Patras, Patras, Greece.
Efthymios KyrodimosFirst Department of Otolaryngology, Hippocration Hospital, University of Athens, Athens, Greece.
Hippocration General Hospital · GRUniversity of Ioannina · GRNIMTS Hospital · GRUniversity of Patras · GRBrighton and Sussex Medical School · GBGeneral Hospital of Athens G. Genimatas · GRNational and Kapodistrian University of Athens · GRPolyclinic General Hospital · GRThe American College of Greece · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among the tumour suppressor genes that affect critically cell functions and homeostasis, phosphatase and tensin homolog deleted in chromosome 10 (PTEN- gene locus: 10q21) regulates the PI3K/Akt/mTOR signalling pathway. PTEN is deleted, mutated or epigenetically hyper-methylated in a variety of human solid malignancies. Salivary gland carcinomas (SGCs) belong to the head and neck carcinomas (HNCs) super category of solid malignancies. Histo-pathologically, they demonstrate a significant diversity due to a variety of distinct and mixed subtypes. Genetically, they are characterized by a broad spectrum of gene and chromosomal imbalances. Referring specifically to suppressor genes, PTEN deregulation plays a critical role in signaling transduction in the corresponding SGC pre- and malignant epithelia modifying the response rates to potential targeted therapeutic strategies. In the current review, we explored the role of PTEN deregulation mechanisms that are involved in the onset and progression of SGCs.

Indexed as

glandmutationPTENreviewsalivarysuppressor gene

Identifiers

PMID38173659
PMCPMC10758848
OpenAlexW4390506789

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.