Evidence map›Paper›PMID 38173540›Full record

ArticleNeurology. Clinical practice2024

Anti-NMDAR Encephalitis Clinical Practice Guideline: Improving Time to Diagnosis, Treatment, and Hospital Length of Stay.

Kelsey M Barter, Catherine Fuchs, Thomas B Graham, Lindsay M Pagano, McKenzie Vater

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Clinical practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kelsey M BarterDivision of Pediatric and Developmental Neurology, Department of Neurology (KMB), Washington University School of Medicine in St. Louis, MO; Division of Child and Adolescent Psychiatry (CF), Departments of Psychiatry and Behavioral Sciences and Pediatrics; Division of Pediatric Rheumatology (TBG); Division of Pediatric Neurology (LMP); and Division of Pediatric Rheumatology (MV), Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN.ORCID https://orcid.org/0000-0002-2079-6558
Catherine FuchsDivision of Pediatric and Developmental Neurology, Department of Neurology (KMB), Washington University School of Medicine in St. Louis, MO; Division of Child and Adolescent Psychiatry (CF), Departments of Psychiatry and Behavioral Sciences and Pediatrics; Division of Pediatric Rheumatology (TBG); Division of Pediatric Neurology (LMP); and Division of Pediatric Rheumatology (MV), Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN.ORCID https://orcid.org/0000-0003-1387-4092
Thomas B GrahamDivision of Pediatric and Developmental Neurology, Department of Neurology (KMB), Washington University School of Medicine in St. Louis, MO; Division of Child and Adolescent Psychiatry (CF), Departments of Psychiatry and Behavioral Sciences and Pediatrics; Division of Pediatric Rheumatology (TBG); Division of Pediatric Neurology (LMP); and Division of Pediatric Rheumatology (MV), Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN.ORCID https://orcid.org/0000-0001-8276-2049
Lindsay M PaganoDivision of Pediatric and Developmental Neurology, Department of Neurology (KMB), Washington University School of Medicine in St. Louis, MO; Division of Child and Adolescent Psychiatry (CF), Departments of Psychiatry and Behavioral Sciences and Pediatrics; Division of Pediatric Rheumatology (TBG); Division of Pediatric Neurology (LMP); and Division of Pediatric Rheumatology (MV), Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN.ORCID https://orcid.org/0000-0002-2153-7187
McKenzie VaterDivision of Pediatric and Developmental Neurology, Department of Neurology (KMB), Washington University School of Medicine in St. Louis, MO; Division of Child and Adolescent Psychiatry (CF), Departments of Psychiatry and Behavioral Sciences and Pediatrics; Division of Pediatric Rheumatology (TBG); Division of Pediatric Neurology (LMP); and Division of Pediatric Rheumatology (MV), Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN.ORCID https://orcid.org/0009-0000-0664-5254

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: A clinical practice guideline (CPG) was created to standardize evaluation and treatment for patients with suspected anti-methyl-d-aspartate receptor (NMDAR) autoimmune encephalitis (AE), the most common AE in children. The objective of this study was to evaluate the CPG effect on time to diagnosis, treatment, and hospital length of stay (LOS). Methods: Patients with an inpatient consult to pediatric rheumatology for AE during a 4-year period (period 2) after CPG implementation were identified. Data were extracted and compared with data over the preceding 4-year period (period 1). Results: During period 1, fewer patients underwent diagnostic testing than during period 2 (34 vs 80). Number of patients diagnosed with AE did not differ from period 1 to that from period 2 (NMDAR AE 9 vs 8; seronegative AE 4 vs 5). The average time to diagnostic evaluation with lumbar puncture decreased from 5.4 to 1.5 days ( Discussion: Creation of a CPG for patients with suspected AE was associated with an improved time to diagnostic evaluation and treatment. With the CPG, more patients underwent AE testing, though total diagnoses remained the same.

Identifiers

PMID38173540
PMCPMC10759001

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