ArticleAnnals of pediatric endocrinology & metabolism2023
Comparison between transient and permanent congenital hypothyroidism on a thyroid function test after re-evaluation.
Article in Annals of pediatric endocrinology & metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Review
- Epidemiological characteristics of congenital hypothyroidism and risk factors for permanent congenital hypothyroidism in Gansu, China.BMC pediatrics · 2026Article
- Permanent or Transient Congenital Hypothyroidism: A Diagnostic Dilemma.Acta paediatrica (Oslo, Norway : 1992) · 2026Review
- Differentiating transient and permanent congenital hypothyroidism: predictive clues from Istanbul, Türkiye.Journal of pediatric endocrinology & metabolism : JPEM · 2025Article
- Predicting variables associated with diagnostic reevaluation of transient congenital hypothyroidism.Annals of pediatric endocrinology & metabolism · 2025Article
- Reconsidering the timing of levothyroxine discontinuation in children with congenital hypothyroidism: insights from a Korean Cohort Study - commentary on "Predicting variables associated with diagnostic reevaluation of transient congenital hypothyroidism".Annals of pediatric endocrinology & metabolism · 2025Article
- Predictive factors of permanent versus transient congenital hypothyroidism: a pragmatic cohort study.Annals of pediatric endocrinology & metabolism · 2025Article
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeCongenital hypothyroidism (CH) is diagnosed with neonatal screening and is treated early in the neonatal period. Among these patients, transient CH (TCH) is included and requires re-evaluation. The purpose of this study was to find the best way to discontinue levothyroxine and to find trends in thyroid function tests (TFTs) after re-evaluation.
methodsWe retrospectively reviewed 388 patients diagnosed with CH. They were classified as permanent CH (PCH) and TCH. The total number of the PCH and TCH groups was 83 (51 boys and 32 girls). We compared clinical parameters to predict TCH and to identify the trends of TFT.
resultsThe first thyroid-stimulating hormone (TSH) value after discontinuation and the average TSH value for 1, 2, and 3 years were all significantly higher in the PCH group (P<0.01). The first fT4 value after discontinuation and the average fT4 value for 1, 2, and 3 years were all significantly higher in the TCH group (P<0.01). The optimal cutoff value on the receiver operating characteristic curve for PCH prediction with an average of 3 years of TSH was greater than 9.05 μIU/mL, which was predicted with a sensitivity of 100% and a specificity of 100%.
conclusionWhen the TSH value ranges from 10 μIU/mL to 20 μIU/mL, clinicians can discontinue levothyroxine if the next result is around 10 μIU/mL or shows a decreasing trend.
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