Evidence map›Paper›PMID 38173288›Full record

SynthesisJournal of Crohn's & colitis2024

Diagnostic Accuracy of Intestinal Ultrasound in the Detection of Intra-Abdominal Complications in Crohn's Disease: A Systematic Review and Meta-Analysis.

Maarten J Pruijt, Floris A E de Voogd, Nahid S M Montazeri, Faridi S van Etten-Jamaludin, Geert R D'Haens, Krisztina B Gecse

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Journal of Crohn's & colitis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  15. [Value of small bowel stenosis in CrohnZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Using ultrasonographic features in pediatric Crohn's disease activity index severity.International journal of physiology, pathophysiology and pharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maarten J PruijtAmsterdam UMC, University of Amsterdam, Gastroenterology and Hepatology, Amsterdam, The Netherlands.ORCID 0000-0002-7457-8353
Floris A E de VoogdAmsterdam UMC, University of Amsterdam, Gastroenterology and Hepatology, Amsterdam, The Netherlands.ORCID 0000-0003-4058-252X
Nahid S M MontazeriAmsterdam UMC, University of Amsterdam, Gastroenterology and Hepatology, Amsterdam, The Netherlands.
Faridi S van Etten-JamaludinAmsterdam UMC, University of Amsterdam, Medical Library, Amsterdam, The Netherlands.
Geert R D'HaensAmsterdam UMC, University of Amsterdam, Gastroenterology and Hepatology, Amsterdam, The Netherlands.
Krisztina B GecseAmsterdam UMC, University of Amsterdam, Gastroenterology and Hepatology, Amsterdam, The Netherlands.

Funding

Amsterdam University Medical Centers
6 · The paper itself

Abstract

backgroundCrohn's disease [CD] is frequently associated with the development of strictures and penetrating complications. Intestinal ultrasound [IUS] is a non-invasive imaging modality ideal for point-of-care assessment. In this systematic review and meta-analysis we provide a current overview on the diagnostic accuracy of IUS and its advanced modalities in the detection of intra-abdominal complications in CD compared to endoscopy, cross-sectional imaging, surgery, and pathology.

methodWe conducted a literature search for studies describing the diagnostic accuracy of IUS in adult patients with CD-related intra-abdominal complications. Quality of the included studies was assessed with the QUADAS-2 tool. Meta-analysis was performed for both conventional IUS [B-mode] and oral contrast IUS [SICUS].

resultsOf the 1498 studies we identified, 68 were included in this review and 23 studies [3863 patients] were used for the meta-analysis. Pooled sensitivities and specificities for strictures, inflammatory masses, and fistulas by B-mode IUS were 0.81 and 0.90, 0.87 [sensitivities] and 0.95, and 0.67 and 0.97 [specificities], respectively. Pooled overall log diagnostic odds ratios were 3.56, 3.97 and 3.84, respectively. Pooled sensitivity and specificity of SICUS were 0.94 and 0.95, 0.91 and 0.97 [sensitivities], and 0.90 and 0.94 [specificities], respectively. The pooled overall log diagnostic odds ratios of SICUS were 4.51, 5.46, and 4.80, respectively.

conclusionIUS is accurate for the diagnosis of intra-abdominal complications in CD. As a non-invasive, point-of-care modality, IUS is recommended as the first-line imaging tool if there is a suspicion of CD-related intra-abdominal complications.

Indexed as

Crohn DiseaseUltrasonographyConstriction, PathologicHumansIntestinal FistulaSensitivity and SpecificityabscessCEUSCrohn’s diseaseDopplerelastographyfistulaIntestinal ultrasoundIUSSICUSstricture

Identifiers

PMID38173288
PMCPMC11147796

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.