Evidence map›Paper›PMID 38173202›Full record

ArticleCurrent molecular medicine2025

IL-1β-Stimulated Bone Mesenchymal Stem Cell-Derived Exosomes Mitigate Sepsis through Modulation of HMGB1/AKT Pathway and M2 Macrophage Polarization.

Yang Li, Zifa Sun, Yuanyuan Li, Jing Sun, Biquan Chen

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Article in Current molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yang LiDepartment of Infectious Diseases, Anhui Provincial Children's Hospital, Hefei, 230022, China.
Zifa SunDepartment of Infectious Diseases, Anhui Provincial Children's Hospital, Hefei, 230022, China.
Yuanyuan LiDepartment of Infectious Diseases, Anhui Provincial Children's Hospital, Hefei, 230022, China.
Jing SunDepartment of Infectious Diseases, Anhui Provincial Children's Hospital, Hefei, 230022, China.
Biquan ChenDepartment of Infectious Diseases, Anhui Provincial Children's Hospital, Hefei, 230022, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSepsis is a life-threatening disease caused by infection, and developing novel strategies against sepsis is still required. Exosomes derived from mesenchymal stem cells (MSCs) have shown promising therapeutic potential for various diseases. In this study, we aimed to investigate the action and mechanism of exosomes derived from IL-1β-pre-conditioned bone marrow-derived mesenchymal stromal cells (BMSCs) in sepsis.

methodsExosomes were isolated from BMSCs that were pretreated with (IL-1β- BMSC/exos) or without IL-1β (BMSC/exos).

resultsIL-1β-BMSC/exos significantly enhanced the proliferation, migration, and tube formation of HUVECs. Treatment with LPS induced the expression of high mobility group box 1 (HMGB1) and the phosphorylation of AKT in HUVECs, but these effects were counteracted by the treatment of IL-1β-BMSC/exos. The protective effect of IL-1β-BMSC/exos on the viability and tube formation ability of HUVECs was reversed by overexpression of HMGB1. Moreover, IL-1β-BMSC/exos promoted the polarization of M2 macrophages and reduced the secretion of inflammatory chemokines. Additionally, IL-1β-BMSC/exos alleviated cecal ligation and puncture (CLP)-induced sepsis

conclusionIL-1β-BMSC/exos alleviates sepsis by modulating the HMGB1/AKT pathway and triggering M2 macrophage polarization.

Indexed as

ExosomesHMGB1 ProteinInterleukin-1betaMacrophagesMesenchymal Stem CellsProto-Oncogene Proteins c-aktSepsisAnimalsCell ProliferationDisease Models, AnimalHumansHuman Umbilical Vein Endothelial CellsLipopolysaccharidesMaleMiceSignal TransductionHMGB1 ProteinHMGB1 protein, humanInterleukin-1betaLipopolysaccharidesProto-Oncogene Proteins c-aktExosomesHMGB1IL-1β-BMSC/exos.M2 macrophage polarizationMesenchymal stem cellsSepsis

Identifiers

PMID38173202

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.