Evidence map›Paper›PMID 38172996›Full record

ArticleBMC nutrition2024

Effects of vitamin B12 supplementation on oxidative stress markers and pro-inflammatory cytokines during pregnancy and postpartum among Bangladeshi mother-child pairs.

Towfida Jahan Siddiqua, Evana Akhtar, Md Ahsanul Haq, Seterah Shahab-Ferdows, Daniela Hampel, Sharmin Islam, Tahmeed Ahmed, Lindsay H Allen, Rubhana Raqib

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01795131 (Role of Vitamin B12 Supplementation During Pregnancy and Postpartum to Reduce Nutritional Anemia and Improve Immunity in Bangladeshi Women and Their Infants), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01795131 phase2 / phase3completednot on this map

Role of Vitamin B12 Supplementation During Pregnancy and Postpartum to Reduce Nutritional Anemia and Improve Immunity in Bangladeshi Women and Their Infants

TypeinterventionalSponsorInternational Centre for Diarrhoeal Disease Research, BangladeshRan2010 to 2013Enrolled120ConditionsNutritional Anemia in Mothers., Nutritional Anemia in Infants.ArmsVitamin B12, Placebo
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Heliyon · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Towfida Jahan SiddiquaInternational Centre for Diarrheal Disease Research, Dhaka, Bangladesh. towfida@gmail.com.
Evana AkhtarInternational Centre for Diarrheal Disease Research, Dhaka, Bangladesh.
Md Ahsanul HaqInternational Centre for Diarrheal Disease Research, Dhaka, Bangladesh.
Seterah Shahab-FerdowsUSDA ARS Western Human Nutrition Research Center, Davis, CA, USA.
Daniela HampelUSDA ARS Western Human Nutrition Research Center, Davis, CA, USA.
Sharmin IslamInternational Centre for Diarrheal Disease Research, Dhaka, Bangladesh.
Tahmeed AhmedInternational Centre for Diarrheal Disease Research, Dhaka, Bangladesh.
Lindsay H AllenUSDA ARS Western Human Nutrition Research Center, Davis, CA, USA.
Rubhana RaqibInternational Centre for Diarrheal Disease Research, Dhaka, Bangladesh.
International Centre for Diarrhoeal Disease Research · BDWestern Human Nutrition Research Center · US

Funding

Nestle Foundation 54100089
6 · The paper itself

Abstract

backgroundThere is limited research to determine whether vitamin B12 (B12) supplementation during pregnancy and lactation is protective against oxidative stress and pro-inflammatory cytokines and whether this effect is transferred to breastfed infants via milk. In addition, associations among maternal plasma/ milk and infant B12 status and immune function markers are poorly characterized.

objectivesTo evaluate effects of oral B12 supplementation during pregnancy and postpartum on maternal and infant 8-hydroxy-2'-deoxyguanosine (8-OH-dG, an oxidative stress marker) and proinflammatory cytokine levels, and examine associations between maternal plasma, breastmilk and infant B12 status as well as immune function markers.

methodIn a blinded, placebo-controlled trial, Bangladeshi women (n = 68, 18-35 years, hemoglobin < 11 g/dL, gestational weeks 11-14) received either 250 μg/day B12 or placebo throughout pregnancy up to 3-months postpartum. Samples were collected from mothers at baseline and 3-months postpartum and from infants at 3-months to measure B12 status indicators, 8-OH-dG and proinflammatory cytokines.

resultsMaternal postpartum B12 was positively associated with infant plasma B12. Higher milk B12 concentrations were associated with increased infant B12 (beta (β) = 277, 95% confidence interval (CI) = (132, 423), p<0.001) and lower total homocysteine (β = -7.63, 95% CI = (-12.40, -2.86), p = 0.002) levels. Maternal B12 supplementation reduced plasma 8-OH-dG concentrations among postpartum mothers and infants compared to the placebo group. Supplementation increased plasma TNF-α and IL-6 levels among mothers and IL-10 and IFN-γ levels among infants.

conclusionMilk and maternal plasma B12 at 3 months were associated with infant B12. Maternal B12 supplementation modulates 8-OH-dG and several cytokines which may protect against immune response-induced oxidative stress.

trial registration(clinicaltrials.gov: NCT01795131- 1

Indexed as

Human milkLactationOxidative stress,cytokinesVitamin B12

Identifiers

PMID38172996
PMCPMC10765711
OpenAlexW4390572189

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.