Trial reportJournal of neuroengineering and rehabilitation2024
Effects of anodal tDCS on resting state eeg power and motor function in acute stroke: a randomized controlled trial.
Trial report in Journal of neuroengineering and rehabilitation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04578080 (Effect of tDCS on Motor Functions and Brain Activity in Acute Stroke Patients), which is not on this map. Cited by 10 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of tDCS on Motor Functions and Brain Activity in Acute Stroke Patients
Who cites it
10 citing papers in PubMed, 4 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Comparative effectiveness of non-pharmacological interventions for post-stroke upper limb motor dysfunction: a systematic review and network meta-analysis of randomized controlled trials.Frontiers in aging neuroscience · 2026Pooled it
- Combined Use of Electroencephalography and Transcranial Electrical Stimulation: A Systematic Review.Sensors (Basel, Switzerland) · 2025Pooled it
- Cerebellar tDCS and pain modulation: a critical integrative and systematic review.Frontiers in neurology · 2025Pooled it
- Examining the effectiveness of motor imagery combined with non-invasive brain stimulation for upper limb recovery in stroke patients: a systematic review and meta-analysis of randomized clinical trials.Journal of neuroengineering and rehabilitation · 2024Pooled it
- Effect of robot-assisted gait training combined with electroacupuncture on lower limb motor function and brain network characteristics in stroke: an EEG study.Journal of neuroengineering and rehabilitation · 2025Trial
- Transcranial direct current stimulation's effect on exercise capacity, respiratory muscle strength, and physical performance in patients with chronic obstructive pulmonary disease: Randomized controlled trial.Chronic respiratory diseaseTrial
- Stroke recovery beyond initial severity: the complementary roles of brain structure and brain function in acute stroke.Brain communications · 2026Article
- Absence of evidence for post-training tDCS effects on motor memory consolidation and premotor-primary motor cortex interaction: a resting-state EEG study.Frontiers in human neuroscience · 2026Article
- Clinical feasibility of motor hotspot localization based on electroencephalography using convolutional neural networks in stroke.Journal of neuroengineering and rehabilitation · 2025Article
- Effect of transcranial direct current stimulation and narrow-band auditory stimulation on the intraoperative electroencephalogram: an exploratoratory feasibility study.Frontiers in psychiatry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAnodal transcranial direct current stimulation (tDCS) is a beneficial adjunctive tool in stroke rehabilitation. However, only a few studies have investigated its effects on acute stroke and recruited only individuals with mild motor deficits. This study investigated the effect of five consecutive sessions of anodal tDCS and conventional physical therapy on brain activity and motor outcomes in individuals with acute stroke, with low and high motor impairments.
methodsThirty participants were recruited and randomly allocated to either the anodal or sham tDCS group. Five consecutive sessions of tDCS (1.5 mA anodal or sham tDCS for 20 min) were administered, followed by conventional physical therapy. Electroencephalography (EEG), Fugl-Meyer Motor Assessment (FMA), and Wolf Motor Function Test (WMFT) were performed at pre-, post-intervention (day 5), and 1-month follow-up. Sub-analyses were performed on participants with low and high motor impairments. The relationship between EEG power and changes in motor functions was assessed.
resultsLinear regression showed a significant positive correlation between beta bands and the FMA score in the anodal group. Elevated high frequency bands (alpha and beta) were observed at post-intervention and follow-up in all areas of both hemispheres in the anodal group, while only in the posterior area of the non-lesioned hemisphere in the sham group; however, such elevation induced by tDCS was not greater than sham. Lower limb function assessed by FMA was improved in the anodal group compared with the sham group at post-intervention and follow-up only in those with low motor impairment. For the upper limb outcomes, no difference between groups was found.
conclusionsFive consecutive days of anodal tDCS and physical therapy in acute stroke did not result in a superior improvement of beta bands that commonly related to stroke recovery over sham, but improved lower extremity functions with a post-effect at 1-month follow-up in low motor impairment participants. The increase of beta bands in the lesioned brain in the anodal group was associated with improvement in lower limb function.
trial registrationNCT04578080, date of first registration 10/01/2020.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.