High-fat Western diet alters crystalline silica-induced airway epithelium ion transport but not airway smooth muscle reactivity.

Janet A Thompson, Michael L Kashon, Walter McKinney, Jeffrey S Fedan

Open access · goldAbstract read

In one paragraph

Article in BMC research notes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

1.1field-weighted citation impact, top 25% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Janet A ThompsonHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA. jsd7@cdc.gov.

Michael L KashonHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA.

Walter McKinneyHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA.

Jeffrey S FedanHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA.

National Institute for Occupational Safety and Health · US

Funding

National Institute for Occupational Safety and Health, Center for Disease Control, US 9390DT3

6 · The paper itself

Abstract

objectivesSilicosis is an irreversible occupational lung disease resulting from crystalline silica inhalation. Previously, we discovered that Western diet (HFWD)-consumption increases susceptibility to silica-induced pulmonary inflammation and fibrosis. This study investigated the potential of HFWD to alter silica-induced effects on airway epithelial ion transport and smooth muscle reactivity.

methodsSix-week-old male F344 rats were fed a HFWD or standard rat chow (STD) and exposed to silica (Min-U-Sil 5

resultsSilica reduced basal I

Indexed as

AmilorideSilicon DioxideAnimalsDiet, WesternEpitheliumIon TransportMaleMethacholine ChlorideMuscle, SmoothRatsRats, Inbred F344AmilorideMethacholine ChlorideSilicon DioxideAirway hyperreactivityEpitheliumIon transportObesitySilicaWestern diet

Identifiers

PMID38172968

DOI10.1186/s13104-023-06672-w

PMCPMC10765734

OpenAlexW4390571203

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.